What Does Urolithin A Do For The Body?

What is the best source of Urolithin A?

Pomegranate: Ellagitannins are one of the richest sources and can be converted into urea A by gut bacteria.
Berries: Strawberries, raspberries and blackberries also contain ellagic acid.
Nuts: Walnuts and other nuts provide ellagic tannins.

What does Urolithin A do for the body?

Scientists from the Swiss Federal Institute of Technology in Lausanne and other institutions have found that the gut metabolite Urolithin A from pomegranates and other fruits may help slow down certain aging processes by improving the function of mitochondria in cells.
UA is a natural compound produced by gut bacteria that ingest ellagic tannins and ellagic acid (a polyphenol found in pomegranates, berries and nuts). Aging is a major risk factor for neurodegenerative diseases, and many hallmarks of aging play a crucial role in the pathogenesis and development of Alzheimer's disease (AD), including impaired autophagy. DNA damage, neuroinflammation, cellular senescence and mitochondrial dysfunction.

1. Mitochondrial Health:

Urea A promotes mitophagy, the process of clearing damaged mitochondria, which is important for maintaining healthy neurons. Mitochondrial dysfunction is a hallmark of Alzheimer's disease.

2. Anti-inflammatory Effects:
Chronic inflammation in the brain is a key feature of Alzheimer's disease. The anti-inflammatory effects of Urea A may help reduce neuroinflammation, potentially slowing the progression of the disease.

3. Neuroprotective Effects:
Urea A has antioxidant properties that help reduce oxidative stress in the brain and protect neurons from damage.

Urea A may support synaptic function, which is important for learning and memory.

4. Animal Studies:
Animal studies have shown that supplementing with Urea A can improve cognitive function and memory in models of neurodegenerative diseases, including Alzheimer's disease.

Pathological Markers: Studies have shown that Urea A can reduce the accumulation of amyloid plaques and tau tangles, which are hallmarks of Alzheimer's disease.

Urea A has the potential to be a therapeutic agent for Alzheimer's disease.