Soft capsules refer to sealed capsule preparations formed by encapsulating oily drugs, drug solutions or drug suspensions in capsule shells made of gelatin as the main material. Common preparation methods include dripping and pressing.
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Softgel capsules have a long history as reliable and stable oral dosage forms, and they are used to deliver active pharmaceutical ingredients, minerals, vitamins or other functional ingredients beneficial to health into the body.
Softgels are sealed capsules containing liquid or semi-solid filled formulas and are ideal for the delivery of oil-based formulations, such as omega-3 fish oil.
Many consumers prefer soft gelatin capsules because they are easy to use and swallow.
Gelatin capsules have excellent performance: they are colorless and odorless, can accurately dose and effectively protect active ingredients in a single dosage form, and are highly bioavailable.
What are softgel capsules most suitable for?
1. Oily drugs and low melting point drugs are suitable for making soft capsules, such as vitamin E.
2. Drugs that are sensitive to light, unstable when exposed to moisture and heat, or easily oxidized can be made into soft capsules. In order to prevent the drug from being decomposed by light, light-shielding materials such as titanium dioxide or iron oxide can be added to the capsule material to achieve good light stability. Such as vitamin D2.
3. Some ingredients that are small in dosage, difficult to dissolve in water, and difficult to be absorbed in the digestive tract can be dissolved in suitable oil and made into soft capsules.
4. Some ingredients have a bitter or stinky taste and are not easily accepted by patients. They can be made into soft capsules with a neat and beautiful appearance and different colors to identify different types of soft capsules.
Reference
[1]. CHEN X L, SEYFANG K, STECKEL H. Development of a micro dosing system for fine powder using a vibrating capillary. Part 1: the investigation of factors influencing on the dosing performance[J]. International Journal of Pharmaceutics, 2012, 433(1/2): 34–41.
[2]. FAULHAMMER E, FINK M, LLUSA M, et al. Low-dose capsule filling of inhalation products: Critical material attributes and process parameters[J]. International Journal of Pharmaceutics, 2014, 473(1/2): 617–626.
