Hirudin Powder

Hirudin Powder

Details
CAS: 113274-56-9
Source: Leech
Specification: 200 to 1200ATU/G or as your requirement
MF: C66h93n13o25
MW:1468.52
Appearance:Brown to gray powder
Capsule available
OEM ODM available
Category
Active Pharmaceutical Ingredients
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Description
Technical Parameters

Hirudin is extracted from the saliva of leeches and undergoes processes such as separation, purification, sterilization and active preservation. 
Its most original state is liquid. The common products in the market are in powder form or capsules.
The hirudin extracted from Japanese leeches has good activity. Experiments have proved that Japanese medical leeches do no harm to the liver and kidneys, are non-toxic and have no side effects, reaching medical standards.

Advantages:

1. Dedicated biotechnology expertise: enzymatic extraction, protein purification and stabilization.
2.Advanced fermentation technology.
3.Protein determination and quantification systems: HPLC, SDS-PAGE or ELISA for hirudin content and purity analysis.

4.Standardized purity and activity testing: for biological activity determination.
5. Contaminant testing: for microbial limits, heavy metals and residual solvents.

6. Stability testing.
7. Rigorous sterilization procedures: including filtration, irradiation or autoclaving (depending on the dosage form).
8. Cold chain logistics: for storage and transportation of active proteins without degradation.

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Hirudin Powder

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Process flow chart 

Hirudin Powder

What is hirudin used for?

1. Hirudin is mainly used for anticoagulation, which helps maintain blood fluidity and prevent thrombosis. This is because, on the one hand, it has a small molecular weight and good permeability, which can easily dissolve blood clots, and on the other hand, it has no serious side effects.
2. Treat heparin-induced thrombocytopenia (HIT).
3. Natural hirudin has the functions of dredging blood vessels, resisting gout, and improving renal function.
4. Used in medical research.

Hirudin

Item

Specification

Result

Active

1000ATU

Conforms

Extract the source

Hirudinaria manillensis lesson

Conforms

Appearance

Fine Powder

Conforms

Color

Brown color

Conforms

Odor

Characteristic

Conforms

Taste

Characteristic

Conforms

Partical Size

100%Through 80 Mesh

Conforms

Loss on Drying

≦5.0%

1.8%

Ash Content

≦5.0%

2.5%

Bulk Density

50-60g/100ml

Conforms

Solvent Residue

Eur.Pharm

Conforms

Pesticide Residue

Negative

Negative

Total Heavy Metals

≤10ppm

Conforms

Arsenic

≤2ppm

Conforms

Lead

≤2ppm

Conforms

Total Plate Count

≤1000cfu/g

Conforms

Total Yeast & Mold

≤100cfu/g

Conforms

E.Coli.

Negative

Negative

Salmonelia

Negative

Negative

Staphylococcus

Negative

Negative

Hirudin

Hirudin

Hirudin

Hirudin

Hirudin

Hirudin

 

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