Paraxanthine Powder | Free Sample

Both have similar stimulating effects, and paraxanthine is safer than caffeine based on in vitro and in vivo clinical studies. It is primarily a major metabolite of caffeine, accounting for about 70% of caffeine intake, and it accounts for about 80% of the amount of caffeine broken down in the liver. 

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1. Product Introduction

Paraxanthine (1,7-Dimethylxanthine) is the primary active metabolite of caffeine, accounting for approximately 70% of caffeine intake and 80% of caffeine hepatic breakdown in the human liver. It delivers stimulatory and nootropic effects similar to caffeine while exhibiting superior safety performance. Multiple in vitro and in vivo clinical studies have proven that paraxanthine causes significantly less cytotoxicity and DNA damage compared with caffeine, making it a safer and milder alternative stimulant and cognitive functional raw material.

We provide high-purity Paraxanthine Powder with factory direct sales, bulk wholesale support and free sample services. Custom OEM processing is available to meet diverse customized production demands for functional raw materials.

Chromatogram：

Dissolve the sample in 50% methanol.

Service: OEM AVAILABLE

1. Paraxanthine has been shown to have many of the same nootropic benefits as caffeine, including improved cognition, short-term memory, sustained attention, and cognitive effects in animal models of Parkinson's disease.
2. In addition, paraxanthine is thought to have beneficial effects on physical endurance and athletic performance.
3. 1,7-Dimethylxanthine also has similar cardiovascular, hormonal, and metabolic effects as caffeine.
4. Both caffeine and paraxanthine act as antagonists of adenosine receptors A1 and A2A. However, paraxanthine appears to exhibit superior binding potency to equine forebrain adenosine A1 and A2A receptors, resulting in a stronger motor activation effect in horses.
5. Paraxanthine causes much less DNA damage and is less cytotoxic.

2.Core Mechanism & Physiological Functions

Paraxanthine shares highly consistent pharmacological activity with caffeine but possesses better safety and milder irritation, with outstanding functional advantages in cognition, exercise performance and physical regulation:

• Powerful Nootropic Effect: Effectively improves overall cognitive ability, enhances short-term memory and sustained attention, and shows positive cognitive improvement effects in Parkinson's disease animal models.
• Boost Athletic Performance & Endurance: Significantly improves physical endurance and exercise adaptability, helping delay fatigue and improve athletic performance.
• Metabolic & Cardiovascular Regulation: Delivers similar cardiovascular, hormonal and metabolic regulatory effects as caffeine, supporting healthy body circulation and energy metabolism.
• High Adenosine Receptor Binding Activity: As an antagonist of adenosine A1 and A2A receptors, paraxanthine shows stronger receptor binding potency, providing more stable motor activation and refreshing effects.
• Superior Biological Safety: Compared with caffeine, paraxanthine greatly reduces cytotoxicity and DNA damage risk, featuring mild action, high safety and no obvious irritation.