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What are the health benefits of Apigenin Powder?

Jul 05, 2022

Apigenin Powder (5,7,4 '- trihydroxyflavone) has a molecular formula of C15H10O5 and a molecular weight of 270.23. Apigenin is a widely distributed flavonoid with various pharmacological activities.

Distribution and Content 

Apium L

Although apigenin is named after celery, its content in Apium L is low, about 0.03-0.88mg/g. The content in petiole is less than that in leaves, and the difference is significant.

Apium L

Chrysanthemum lavandulifolium

Chrysanthemum lavandulifolium

(Fisch.ex Trautv.)

Ling et Shih

The content of apigenin in chrysanthemum lavandulifolium is generally high. As the preferred variety of chamomile, Chrysanthemum morifolium is rich in apigenin, which is about 3-6mg/g, more than 100 times that of celery.


What are the health benefits of apigenin powder? 

 Soothing Effect:

In the experiment of mice, apigenin injection has a significant sedative effect on mice, which is the same as the traditional anti-anxiety drug benzodiazepines (BDZ). Apigenin can bind to the BDZ receptor of the gaba-bdz-c1 receptor complex and play an anti-anxiety role by enhancing GABAergic neurotransmission. However, compared with BDZ, apigenin has only a weak sedative and hypnotic effect, and will not produce muscle relaxation and anticonvulsant effects, so the side effects are greatly reduced.

Vasodilation

Apigenin can enhance the vasodilating effect of acetylcholine. After removing the vascular endothelium, it is found that it still has a vasodilating effect but is weakened, indicating that its target includes vascular endothelial cells in addition to vascular smooth muscle cells, the preliminary mechanism study showed that the effect of apigenin on phenylephrine vasoconstriction was not only related to blocking ca2+ influx by regulating ca2+ channels but also related to the release of no and the rise of cGMP level.

Apigenin Powder

Inhibition of arteriosclerosis and thrombosis 

Apigenin also has favorable effects in inhibiting arteriosclerosis and thrombosis. arteriosclerosis and thrombosis are closely related to the hyperactivity of platelets, in which there are epoxidase and lipoxygenases, two enzymes that act on the arachidonic acid metabolic system to produce thromboxane A2 (TXA2), which forms thrombi, and 12 hydroxyeicosatetraenoic acid (12-HETE), which causes allergic diseases and arteriosclerosis.TXA2 is unstable and rapidly generates stabilized thromboxane B2 (TXB2). Apigenin inhibits TXB2 formation in platelets, whereas apigenin-7-o- β- D-glucuronide significantly reduces 12-HETE production, indicating that apigenin and its glycosides may counteract arteriosclerosis and thrombosis by inhibiting the arachidonic acid metabolic pathway in platelets.

Diet Therapy 

Apigenin Powder is widely distributed in vegetables and fruits in the temperate zone and is also found in high amounts in some medicinal plants such as psyllium, complex stone vine, and so on, as well as in plant-derived beverages such as tea, wine, and some condiments.

Diet Tyerapy

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