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Horse Chestnut Extract Esculin is a kind of coumarin compound extracted from the dry bark or bark of Carpinus avigata, a plant of Carpinus avigata. It is the active ingredient of Chinese traditional medicine Pinus avigata. Under normal temperature, it is white crystalline powder with slightly bitter smell. Aesculin and its glycoside, Aesculetin Chemicalbook, were effective in the treatment of bacterial dysentery and tracheitis. In addition, it also has anti-inflammatory, anti-bacterial, anti-coagulant, analgesic and other activities, and has a significant diuretic effect on mice. It can inhibit the aldose reductase of rat eye lens, is the growth inhibitor of Bacillus subtilis, and also has the inhibitory effect on chemical cancer.
1. Anti-inflammatory and analgesic: intraperitoneal injection of 10mg/kg in rats has inhibitory effects on carrageenan, dextrose liver, serotonin and histamine "arthritis", and the inhibitory strengths are respectively 35,28,20,8%. Horse Chestnut Extract Esculin has also been reported that it also has an inhibitory effect on formaldehyde-induced "arthritis", but its effect is weaker than that of carrageenan-induced "arthritis"; it does not inhibit dextran-induced "arthritis". Obviously. It has inhibitory effect on the formation of rat granuloma (cotton ball method), the erythema reaction caused by ultraviolet radiation on the back of guinea pigs, and the increase of capillary permeability caused by histamine. It has a weak analgesic effect.
2. Effect on urine output and uric acid excretion: Various routes of administration can increase uric acid excretion in rats and rabbits. It has no diuretic effect on normal rats, but has a significant diuretic effect on mice. 3. Others: it has antibacterial, anti-coagulation and inhibition of aldose reductase of rat eye lens.
Mainly produced in Northeast China, Hebei and Henan, Inner Mongolia, Shaanxi, Shanxi and the Yangtze River Basin also produced, all over the wild or cultivated
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