Dihydroberberine Powder

Dihydroberberine powder (DHB) is a metabolite of berberine. Dihydroberberine is synthesized from berberine by reduction reaction.

In the body, DHB is converted into berberine through the dihydroxylation process. Two hydrogen atoms are added to the molecular structure of berberine, and then dihydroberberine is formed. Dihydroberberine is a yellow crystal that is soluble in organic solvents such as methanol, ethanol, and DMSO. The potential of dihydroberberine in controlling metabolic diseases such as diabetes and obesity has been studied.

Or other forms of berberine products(such as Berberine hydrochloride, tetrahydroberberine) we can also provide.

Both Dihydroberberine capsules and powder are available.The company provides consulting, product design, raw material procurement, sampling, manufacturing, quality control, customized packaging and transportation.

1. Product Introduction

Dihydroberberine (DHB) is a high-activity hydrogenated metabolite and reduced derivative of Berberine. It is synthesized through a specific reduction reaction, whereby two hydrogen atoms are added to the molecular structure of berberine. In the human body, DHB can be further converted into berberine via dihydroxylation, endowing it with better bioavailability and metabolic adaptability compared with ordinary berberine.

Dihydroberberine appears as light yellow crystalline powder. It is easily soluble in common organic solvents including methanol, ethanol and DMSO. Modern pharmacological studies have verified its outstanding potential in improving glucose metabolism, regulating intestinal flora, and intervening metabolic diseases such as obesity and diabetes. We provide a full range of berberine series products, including Berberine Hydrochloride and Tetrahydroberberine, with customizable powder and capsule dosage forms. We also support one-stop OEM services covering product design, sampling, production, quality control and customized packaging.

Product Synonyms: Dihydroumbellatine, 7,8-Dihydroberberine, Glucovantage, DHB Berberine, Dihydroberberine SR, Dihydroberberine Hydrochloride, Dihydroberberine Sulfate

2.Core Functions & Pharmacological Benefits

• Optimize Intestinal Flora & Intestinal Health: DHB can effectively regulate the structure of intestinal microbiota, increase beneficial intestinal bacteria levels and reduce harmful flora, improving intestinal microecological balance and maintaining long-term intestinal health.
• Protect Cardiovascular Health: Possesses significant anti-myocardial ischemia and anti-arrhythmia effects. It inhibits vascular atherosclerosis, relieves vascular inflammation, and assists in lowering blood pressure and cholesterol to protect cardiovascular function.
• Improve Metabolic Health: Optimizes insulin sensitivity, effectively regulates blood glucose and blood lipid levels, improves glucose metabolism disorders, and provides natural intervention for obesity, diabetes and other metabolic syndromes.
• Protect Nerves & Improve Cognition: Upregulates the expression of brain vascular growth factors and related adhesion molecules, reduces Aβ deposition in the brain, inhibits neuronal apoptosis, promotes cerebral microcirculation repair, and improves cognitive dysfunction.
• Powerful Anti-inflammatory Activity: Regulates NF-κB and MAPK signaling pathways to inhibit inflammatory responses, reducing chronic low-grade inflammation in the body.

3.Main Application Fields

Pharmaceutical Raw Materials: Used for the research and preparation of intestinal flora regulators, cardiovascular protection drugs and metabolic disease intervention drugs.

Health & Nutritional Supplements: Widely applied in blood sugar regulation, lipid-lowering, intestinal health and cardiovascular care functional health products.

Functional Food & Beverage: Added as a safe functional raw material in daily functional foods and beverages for metabolic health maintenance.

4. Product Service & Customization

We supply high-purity Dihydroberberine powder and finished capsules, alongside a complete lineup of berberine derivatives including berberine hydrochloride and tetrahydroberberine. We provide full-chain services including technical consultation, product formula design, raw material customization, sample provision, OEM production, strict quality inspection, customized packaging and global transportation.

1. For the preparation of drugs that regulate intestinal flora.
2. Used in nutritional products, health care products.
3. Food and Beverage.

Reference

[1]. Tan L., Wang Y., Ai G., Luo C., Chen H., Li C., Zeng H., Xie J., Chen J., Su Z. Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways. Int. Immunopharmacol. 2019;75:105802. doi: 10.1016/j.intimp.2019.105802.

[2]. Buchanan B., Meng Q., Poulin M.M., Zuccolo J., Azike C.G., Gabriele J., Baranowski D.C. Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine. PLoS ONE. 2018;13:e0194979. doi: 10.1371/journal.pone.0194979.