Dihydroberberine Powder

Dihydroberberine powder (DHB) is a metabolite of berberine. Dihydroberberine is synthesized from berberine by reduction reaction.

In the body, DHB is converted into berberine through the dihydroxylation process. Two hydrogen atoms are added to the molecular structure of berberine, and then dihydroberberine is formed. Dihydroberberine is a yellow crystal that is soluble in organic solvents such as methanol, ethanol, and DMSO. The potential of dihydroberberine in controlling metabolic diseases such as diabetes and obesity has been studied.

Or other forms of berberine products(such as Berberine hydrochloride, tetrahydroberberine) we can also provide.

Both Dihydroberberine capsules and powder are available.The company provides consulting, product design, raw material procurement, sampling, manufacturing, quality control, customized packaging and transportation.

1. The dihydroberberine powder composition can significantly increase the level of the first intestinal microbiota in the subject, while reducing the level of the second intestinal microbiota in the subject, thereby improving intestinal health.
2. Dihydroberberine has anti-myocardial ischemia and arrhythmia effects.
3. Dihydroberberine is beneficial to cardiovascular health, has anti-inflammatory and anti-atherosclerotic properties, and is beneficial for lowering blood pressure and lowering cholesterol levels.

4. Berberine can enhance the expression of platelet-endothelial cell adhesion molecules, vascular endothelial growth factor (VEGF), human angiopoietin-1, etc. in the brain, reduce Aβ accumulation and inhibit neuronal apoptosis, and promote the formation of cerebral microvessels and cerebral blood circulation. Flow restoration and improvement of cognitive dysfunction.
5. DHB can improve insulin sensitivity, lower blood sugar levels, and lower blood lipids.
6. It has a positive effect on metabolism, such as improving glucose metabolism.

1. For the preparation of drugs that regulate intestinal flora.
2. Used in nutritional products, health care products.
3. Food and Beverage.

Reference

[1]. Tan L., Wang Y., Ai G., Luo C., Chen H., Li C., Zeng H., Xie J., Chen J., Su Z. Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways. Int. Immunopharmacol. 2019;75:105802. doi: 10.1016/j.intimp.2019.105802.

[2]. Buchanan B., Meng Q., Poulin M.M., Zuccolo J., Azike C.G., Gabriele J., Baranowski D.C. Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine. PLoS ONE. 2018;13:e0194979. doi: 10.1371/journal.pone.0194979.