Nicotinamide Riboside Hydrogen Malate is an advanced, highly stable salt form combining Nicotinamide Riboside (NR) with hydrogen malate (an active organic conjugate of malic acid).
While standard NR serves as an efficient direct precursor to NAD+ (Nicotinamide Adenine Dinucleotide), the malate conjugate acts directly within the mitochondrial Krebs cycle (citric acid cycle). This pairing creates a dual-action mechanism:
The NR moiety elevates the intracellular NAD+ pool required for ATP synthesis, sirtuin activation, and PARP-mediated DNA repair.
The Malate moiety feeds intermediate substrate into mitochondrial respiration, driving direct ATP regeneration and muscle endurance.
The result is superior mitochondrial synergy compared to conventional NAD+ precursors.
Other related products available
NICOTINAMIDE RIBOSIDE powder 98%
Nicotinamide Riboside Supplement
Synergy with hydrogen malate
Malic acid is a component of the citric acid cycle, which is a core process for cellular energy production. When combined with NR, malic acid provides additional support for mitochondrial function to achieve energy-enhancing effects.
Available in powder and other forms.
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| Test Items | Specification | Result | MOA |
| Appearance | White to off-white powder | Off-White Powder | Visual |
| Purity | ≥98.0 % | 99.8 % | HPLC |
| Water | ≤2 % | 0.17 % | KF |
| Organic Solvents | ≤0.1 % | 0.03 % | GC |
| Heavy metal content | |||
| Pb | ≤0.1 ppm | Conform | GB5009 |
| Hg | ≤0.1 ppm | Conform | GB5009 |
| Cd | ≤0.2 ppm | Conform | GB5009 |
| As | ≤0.1 ppm | Conform | GB5009 |
| Total microbial count | ≤500 CFU/g | <10 | GB4789 |
| Coliform | ≤0.92 MPN/g | Conform | GB4789 |
| Mold and yeast | ≤50 CFU/g | Conform | GB4789 |
| Staphylococcus aureus | 0/25 g | Conform | GB4789 |
| Salmonella | 0/25 g | Conform | GB4789 |
| Conclusion: | Meet the In-house standard | ||
Key Health Benefits & Biological Mechanisms
Potent NAD+ Elevation: Bypasses conventional biosynthetic rate-limiting enzymes to rapidly increase circulating and cellular NAD+ concentrations.
Mitochondrial Support & Vitality: Synergistic malate utilization optimizes energy metabolic flux, combating age-related cellular fatigue and enhancing athletic endurance and post-exercise recovery.
Sirtuin Activation & Healthy Longevity: Replenishes the co-substrate required for SIRT1 and SIRT3 activation, regulating epigenetic health, mitochondrial biogenesis, and cellular longevity pathways.
DNA Integrity & Genomic Stability: Fuels Poly(ADP-ribose) Polymerases (PARP enzymes) critical for rapid repair of single-strand DNA breaks and protection against oxidative insult.
Neuroprotection & Cognitive Longevity: Promotes neuronal bioenergetics, resists cerebral oxidative stress, and preserves synaptic plasticity.
Cardiometabolic Optimization: Supports vascular endothelial resilience, nitric oxide synthase function, and healthy insulin signaling cascades.
Finished Product & OEM/ODM Capabilities
Suitable for broad formulation matrices due to high purity, excellent solubility, and moisture control:
Dosage Formats: Two-piece hard capsules, compressed tablets, powder drink mixes, stick packs, and effervescent formulations.
Related Active Ingredients in Portfolio:
Nicotinamide Riboside Chloride (NR-Cl) Powder 98%
Reduced Nicotinamide Mononucleotide (NMN)
Pure Nicotinamide (Vitamin B3) Powder
Coenzyme Q10 (Ubiquinone / Ubiquinol)
Resveratrol & Pterostilbene
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