Nicotinamide Riboside Supplement

PRODUCT OVERVIEW & CELLULAR NAD+ PHARMACOKINETICS

Nicotinamide Riboside (NR) is a next-generation pyridine-nucleoside and a direct physiological precursor to Nicotinamide Adenine Dinucleotide (NAD+). NAD+ is an essential coenzyme found in every living cell, driving mitochondrial oxidative phosphorylation (converting ADP to ATP) and acting as an obligate co-substrate for Sirtuins (SIRT1-SIRT7 longevity enzymes) and Poly(ADP-ribose) Polymerases (PARP DNA repair enzymes).

Why NR Outperforms Traditional Vitamin B3 Forms:

Superior Cellular Kinase Pathway: Unlike Niacin (which triggers severe cutaneous flushing) or standard Nicotinamide (NAM, which inhibits sirtuins at elevated concentrations), NR enters cells directly via equilibrative nucleoside transporters (ENTs) and is phosphorylated by NR kinases (NRK1 and NRK2) directly into Nicotinamide Mononucleotide (NMN, CAS 1094-61-7), which is then adenylated into NAD+ via NMNAT enzymes.

Rapid NAD+ Elevation: Clinical pharmacokinetic trials prove that oral NR supplementation elevates circulating whole-blood NAD+ pools by 40% to 50% within 2 weeks at 300 mg/day, and up to 140%-150% at 1,000 mg/day in a predictable, dose-dependent manner.

High Bioavailability & Methyl Balance: Our advanced stabilization and crystal engineering protect the ribosidic bond from premature cleavage by purine nucleoside phosphorylase (PNP), ensuring maximum intracellular delivery and cellular retention.

Our formula ensures high levels of absorbability and bioavailability, with close to 100% absorption, and is tested for potency and safety.

Optimized formula:

1. Nicotinamide Riboside + Trans-Resveratrol
2. NR+Resveratrol+Quercetin
3. Nicotinamide Riboside + Berberine + Resveratrol + Spermidine + Fisetin + Quercetin + Apigenin

4. Resveratrol + Berberine + Fisetin+ Quercetin+Grape Seed Extract+ Milk Thistle+ Green Tea Extract

CORE HEALTH BENEFITS & PHARMACOLOGICAL MECHANISMS

Cellular Bioenergetics & ATP Restoration: By replenishing the intracellular NAD+/NADH ratio, NR boosts electron transport flux across Mitochondrial Complexes I and IV, overcoming metabolic fatigue, enhancing muscle fiber contractile power, and reversing age-related mitochondrial decay.

Epigenetic Maintenance & Sirtuin Activation: Elevated NAD+ activates SIRT1 (nuclear longevity and autophagy regulation) and SIRT3 (mitochondrial oxidative stress defense), deacetylating downstream targets like PGC-1alpha to stimulate mitochondrial biogenesis and defend against metabolic syndrome.

Neuroprotection & Brain Metabolic Restoration: Clinical investigations reveal that oral administration of 1,000 mg NR daily significantly increases cerebral NAD+ and its metabolome, lowers neuroinflammatory markers, and enhances neurovascular coupling. In preclinical models of neurodegenerative conditions (including Parkinson's and Alzheimer's disease), NR protects dopaminergic neurons, halts neuroinflammation, and improves motor coordination.

Healthy Aging & Physical Vigor in Older Adults: A landmark clinical trial published in the European Journal of Nutrition verified that regular NR supplementation in elderly populations significantly dampens systemic oxidative stress and inflammatory cytokine expression while measurably enhancing skeletal muscle function and mobility.

DNA Repair & Genomic Integrity: Replenishes the obligatory cofactor consumed by Poly(ADP-ribose) Polymerases (PARP-1 and PARP-2), facilitating single-strand DNA break repair and preventing genomic instability induced by environmental radiation and oxidative toxins.

On the one hand, NAD+ is a very important coenzyme in the redox reaction of organisms, helping to convert adenosine diphosphate (ADP) into adenosine triphosphate (ATP). On the other hand, NAD+ is a cosubstrate for a variety of enzymatic reactions.

1. At the cellular level, after NR enters the cell, it can be phosphorylated by NR kinases NRK1 and NRK2 to become CAS 1094-61-7, or deribosylated to become NAM under the action of purine nucleoside phosphorylase.

Several clinical studies have confirmed that NR is beneficial to metabolism, and supplementing CAS 1094-61-7 or NR can reverse aging and prolong life.

2. Researchers have observed that taking 1000mg NR per day can increase NAD in the brain. The authors of the study believe that NR treatment can increase NAD and its metabolites in the brain, or improve Parkinson's disease.
3. A study published in the European Journal of Nutrition in 2019 found that taking nicotinamide riboside supplement can improve the physical function of the elderly and reduce oxidative stress. It is more effective for the elderly population.

Reference

[1]. Lee HJ, Yang SJ. Supplementation with nicotinamide riboside reduces brain inflammation and improves cognitive function in diabetic mice. Int J Mol Sci 2019;20(17). pii: E4196. View abstract.

[2]. Yoshino J, Baur JA, Imai SI. NAD+ intermediates: the biology and therapeutic potential of CAS 1094-61-7 and NR. Cell Metab 2018;27(3):513-28. View abstract.