Bimatoprost powder is a synthetic prostaglandin drug. It is marketed as Lumigan in the United States, Canada and Europe. As a prostaglandin F2α analog, it can effectively reduce intraocular pressure and promote hair growth.
Chromatogram:
|
TESTS |
SPECIFICATIONS |
RESULTS |
|
|
Purity |
NLT99.0% |
99.89% |
|
|
Descriptior |
White powder |
White powder |
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|
Identification(by HPLC) |
RT of the sample should match with standard in the Related substances |
Complies |
|
|
Solubility |
Very soluble in ethanol,methanol slightly soluble in water |
Complies |
|
|
Water |
NMT 1.0% |
0.60% |
|
|
Specific rotation[a]20 (C=2,CH₃OH) |
Between +33° to +39° |
+37.1° |
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|
Residue on ignitior |
NMT 0.1% |
0.04% |
|
|
Heavy metals |
NMT 10ppm |
Complies |
|
| Residual solvent | |||
|
Isopropanol Ethyl acetate Methyl tert-butyl ether N.N-Dimethylformamide |
NMT 0.5% NMT 0.5% NMT 0.5% NMT 0.088% |
Not Not Not Not |
detected detectec detected detected |
|
Related Substances(by HPLC 15β-bimatopros 15-Keto derivative 5,6-trans isomer Other single max impurity Total other impurities |
NMT0.2% NMT0.2% NMT0.2% NMT0.1% NMT0.5% |
0.02% 0.01% 0.08% Not detected Not detected |
|
Does bimatoprost grow hair?
1. It is mainly used to treat glaucoma and high intraocular pressure symptoms. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eye.
2. Clinically, it was found that some patients who used bimatoprost would have eyelash growth, increase, and growth. After that, bimatoprost was used in clinical trials for eyelash beauty and was approved by the US FDA in December 2008 as an ingredient to promote eyelash growth. However, it needs to be used under professional guidance and in accordance with the requirements of the product instructions.
3. In vitro culture of human hair follicle cells, three groups of controlled control trials found that after using bimatoprost, the in vitro cultured hair would be healthier, grow faster and longer, which seems to prove that bimatoprost can make hair grow faster and longer. However, this experiment was an in vitro culture and short-term culture experiment.
1. As an ingredient in eyelash growth fluid, bimatoprost has a high safety risk when used for eyelash growth. Its FDA pregnancy rating is C, and it may have adverse effects on the fetus. Its safety needs to be further evaluated.
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