Progesterone is mainly secreted by the corpus luteum in the ovaries and is a very important steroid hormone in female vital signs. Female endocrine hormones coordinate menstruation and fertility through complex stimulatory and inhibitory signals. Together with estrogen, it regulates organ functions related to the menstrual cycle.
Progesterone Powder appears as white or off-white crystalline powder, odorless.
COA of Progesterone
According to EP10
| Items | Requirements | Results |
| Ref standard | According to EP10 | |
| Purity | ≥99.2% | 99.78% |
| Assay | 97%-102% | 99.21% |
| Appearance | White or almost white crystalline powder,odorless | Conforms |
| Identification | A:IR B:TLC | Conforms |
| Melting point | 126℃-131℃ | 128℃-129.1℃ |
| Loss on drying | ≤0.5% | 0.17% |
| Specific optical rotation | +186°~+194° | +188° |
| Single impurity | ≤0.5% | 0.18% |
| Total impurities | ≤0.8% | 0.22% |
| Conclusion: | The items tested conform to the requireaents of EP10 | |
According to USP43
|
Item |
Requirements |
Results |
|
Appearance |
White or almost white crystalline powder |
Conforms |
| Standard | USP43 | / |
|
Assay |
97%-103% |
99.15% |
| Particle size | 90%＜10UM | Conforms |
| Specific optical rotation | +175°~+183° | +181° |
| Loss on drying | ≤0.5% | 0.17% |
| Melting point | 126℃-131℃ | 127℃-129.2℃ |
| Identification | A:IR B:UV | Conforms |
1. Used for tire protection. Progesterone has the function of promoting the growth of glands in the uterine mucosa. For women with sufficient progesterone secretion, their fetuses will develop safely and help reduce the possibility of women suffering from gynecological diseases.
Progesterone can protect the endometrium of women, especially during pregnancy. Progesterone hormone can provide support and guarantee for the early growth and development of the fetus.
Progesterone provides favorable conditions for the implantation of the pregnant egg and is an important hormone in maintaining pregnancy.
Inhibits uterine contractions and reduces the sensitivity of the uterus to oxytocin, allowing the fetus to grow safely.
2. Progesterone is one of the hormones that promotes normal development of female breasts and also plays a role in maintaining female breasts.
3. For the treatment of dysfunctional uterine bleeding caused by luteal insufficiency.
4. Progesterone is also used to understand the function of the corpus luteum, determine whether ovulation occurs, and assist in the diagnosis of threatened abortion.
1. Progesterone powder is used to produce progesterone preparations, and commonly used dosage forms include injections and tablets. Clinically, progesterone drugs are mainly used to treat threatened abortion, habitual abortion, premenstrual stress syndrome, anovulatory amenorrhea, etc.
2. Widely used in assisted reproduction.
Reference
[1].Putnam CD, Brann DW, Kolbeck RC, Mahesh VB. Inhibition of uterine contractility by progesterone and progesterone metabolites: mediation by progesterone and gamma amino butyric acidA receptor systems. Biol Reprod. 1991 Aug;45(2):266-72.
[2]. Lawrenz B., Melado L., Fatemi H. Premature Progesterone Rise in ART-Cycles. Reprod. Biol. 2018;18:1–4. doi: 10.1016/j.repbio.2018.01.001.
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