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What is 20(S)-Ginsenoside Rg3?

Nov 26, 2020

20(S)-Ginsenoside Rg3 is a product after ginseng cooking and processing, with a content of three parts per 100,000 in red ginseng. Its natural scarcity leads to its super-high use value.

1. Interpreting Rg3 from the source:

Ginsenoside Rg3 is derived from the root of ginseng. It is a natural component produced during the process of cooking and processing ginseng into red ginseng. The content is very rare, only containing three hundred thousandths, it does not exist in fresh and dried ginseng.

20(S)-Ginsenoside Rg3

2. Interpreting Rg3 from the perspective of Chinese medicine chemistry:

20(S)-Ginsenoside Rg3 is a molecular in traditional Chinese medicine ginseng. It is a single component separated from ginsenoside powder using modern scientific extraction .

A large number of scientific experiments and clinical studies have shown that ginsenoside Rg3 has strong stability , so it can better exert medicinal value.

3. Interpreting Rg3 from market value:
Because Rg3 is only three hundred thousandths scarce in ginseng and its powerful effects on human health, Rg3 has a high market value. In the international market, 1 mg of high purity Rg3 is US$500, which is comparable diamond in market .

market value

4. Anticancer mechanism of ginsenoside Rg3:

Anticancer mechanism of ginsenoside Rg3

(1) Inhibit tumor cell proliferation:

20(S)-Ginsenoside Rg3 mainly acts on the G2 phase, which can effectively inhibit the synthesis of protein and ATP in the pre-mitotic phase of tumor cells, and slow down the proliferation of tumor cells, thereby controlling the growth rate of tumor cells and inhibiting the proliferation of tumor cells.

(2) Induce tumor cell apoptosis:

①Rg3 can promote tumor cells to initiate the process of apoptosis, thereby inducing tumor cell apoptosis.

②Rg3 can also activate cyclin kinase and make cells stagnate in G1 phase.

③It can enhance the ability of NO production, and NO can induce cell apoptosis.

④Rg3 can also induce apoptosis of a variety of tumor cells through the mitochondrial pathway.

(3)Inhibit tumor cell infiltration and metastasis:
The main function of Rg3 is to inhibit tumor cells from infiltrating the basement membrane, inhibit the adhesion and invasion of tumor cells with fibronectin and laminin, thereby inhibiting tumor infiltration and metastasis.

(4) Inhibit tumor angiogenesis:

A large amount of experimental data proves that Rg3 can effectively inhibit the expression of two growth factors, thereby fundamentally preventing tumor angiogenesis.

(5) Reversing drug resistance of tumor cells:

Rg3 competes with the drug to bind to the P glycoprotein encoded by MDR-1 to reduce the expression of P glycoprotein and reduce the emergence of drug resistance.

(6) Improve immunity:

① Promote the proliferation of lymphocytes, including T lymphocytes and B lymphocytes, and improve immunity by increasing the number of immune cells.

②Increase the phagocytic function of monocytes and macrophages. Monocytes and macrophages are important immune cells in the body, which have important functions such as anti-infection, anti-tumor and immune regulation.

③ Improve NK cell activity. Natural killer cell (NK) is an important immune cell of the body, which is not only related to anti-tumor, anti-viral infection and immune regulation, but also participates in the occurrence of hypersensitivity and autoimmune diseases in some cases.


(7) Helping transplant patients' immune reconstruction:

Rg3 mainly enhances the number and activity of T cells after organ transplantation, and participates in the body's immune reconstruction. By establishing the body's free immune system, on the one hand, it promotes the fusion of transplanted organs and the body; on the other hand, it prevents infection and recurrence of disease.

(8) Reduce side effects of radiotherapy and chemotherapy:

①Rg3 has antiemetic effect to overcome the symptoms of digestive tract discomfort, including low appetite, low food intake, nausea, and vomiting.

②Rg3 can speed up the repair time of normal cells, reduce the damage of the digestive tract mucosa, and have a therapeutic effect on gastric ulcer and duodenal ulcer.

③Rg3 can improve constipation, especially constipation related to poor sleep.

④Rg3 regulates the normal operation of electrolytes and their ions, especially calcium and potassium ions, and protects the normal function of the heart.

(9) Increase the efficacy of radiotherapy and chemotherapy:

Rg3 improves the sensitivity of tumors to chemotherapy drugs. Improve the efficacy of chemotherapy drugs or radiotherapy, which is significantly higher than that of radiotherapy and chemotherapy alone. The clinical effective rate for non-small cell lung cancer is 38-40%, liver cancer 35%, breast cancer 50%, and leukemia 82%.

Ginsenoside Rg3

(10) Preventive effect on high-risk tumor population:
Ginsenoside Rg3 has a significant inhibitory effect on a variety of oncogenes in the human genome or genes that cause tumorigenesis, invasion and metastasis, at least down-regulating the expression of oncogenes in the human genome by more than 2 times, and can be down-regulated by more than 9.7 times.

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