Diabetes medication for weight loss
Bariatric surgery and Roux-en-Y may provide long-term protection from complications for people with a high body mass index (BMI). In addition to lifestyle changes and bariatric surgery, pharmacotherapy is an important alternative or complementary treatment for weight loss.
GLP-1 receptor agonist drugs such as liraglutide, semaglutide can help reduce appetite, slow gastric emptying, and promote weight loss by mimicking the effects of the incretin hormone. They are available in injectable form and are also approved to treat obesity.
Weight loss medication online
Semaglutide structure and mechanism of action:
Semaglutide has beneficial effects on several important organs including the pancreas, heart, and liver.
Semaglutide is a glucagon-like peptide-1 receptor agonist used as an adjunct to diet and exercise to promote glycemic control in adults with type 2 diabetes. Its mechanism of action is as follows:
Semaglutide is a GLP-1 analog with 94% sequence homology to human GLP-1. As a GLP-1 receptor agonist, it can bind to the GLP-1 receptor and activate the receptor, thereby lowering blood sugar by stimulating insulin secretion and reducing glucagon secretion. In addition, Semaglutide can act on the digestive tract, delaying gastrointestinal emptying to increase satiety and suppress appetite.
Glp 1 for weight loss
Research on GLP-1 was initially aimed at treating diabetes. In the early 1980s, GLP-1 was discovered during research on blood sugar regulation. In 2005, the first GLP-1 drug was approved for type 2 diabetes. What really makes GLP-1 popular is its excellent weight loss effect. GLP-1 is mainly secreted by intestinal L cells, but it is widely distributed in the human body.
Studies have found that GLP-1 can directly or indirectly have a positive effect on the cardiovascular system (acting on the cardiovascular system, repairing damaged intima, and improving endothelial function), nervous system, kidneys, liver, bone, etc. through its metabolic regulation function. , so breakthroughs are expected in the fields of cardiovascular disease, non-alcoholic fatty liver disease, Alzheimer's disease and other fields.
Probiotics for weight loss
Probiotics are live bacteria and yeasts that are good for digestive health. Some studies suggest that certain strains of probiotics may aid weight loss; the effects on weight loss may vary based on individual constitution and strains of probiotics, and are generally considered safe.
So how do probiotics affect weight loss?
Gut flora: Probiotics can help maintain a healthy balance of gut bacteria, which is important for digestion, metabolism and overall health. Imbalances in gut bacteria are associated with obesity and metabolic disorders.
Reduce inflammation: Some probiotic strains may help reduce inflammation in the body, which is thought to be a cause of obesity and weight gain.
Improved insulin sensitivity: Probiotics may help improve insulin sensitivity, which affects how your body stores and uses fat.
Research on probiotic strains for weight loss:
Research shows that certain strains of lactic acid bacteria, such as Lactobacillus fermentum and Lactobacillus fermentum, and Bifidobacterium, may aid weight loss by affecting gut bacteria and reducing inflammation.
Reference
[1].The short half-life of glucagon-like peptide-1 in plasma does not reflect its long-lasting beneficial effects. DOI: 10.1530/eje.0.1460863.
[2].Glucagon-like peptide-1 therapy in people with obesity restores natural killer cell metabolism and effector function. DOI: 10.1002/oby.23772.
[3].Hsieh F C , Lan C C E , Huang T Y , et al. Heat-killed and live Lactobacillus reuteri GMNL-263 exhibit similar effects on improving metabolic functions in high-fat diet-induced obese rats[J]. Food & Function, 2016:2374-2388.
