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Studies on the anti-aging effect of beta-nicotinamide mononucleotide (nmn)

Mar 29, 2022

In the last article, I said that I would summarize some of the latest research on beta-nicotinamide mononucleotide (NMN), mainly referring to anti-aging.


Redox Biology has published a study showing that β-nicotinamide (NMN) supplementation confers significant cerebrovascular protection in aged mice, which can improve NVC responses in the aged cortex consistent with its leading dementia. Follow up progress results for the study were published in February 2020 at GeroScience, Team taking gene expression as a starting point, the results found that compared with the generally aged mice, Aged mice injected with nicotinamide mononucleotide had changes in the expression of 590 neurovascular related genes, expression levels of 204 of these returned to the young mouse level.

In February 2021, Prof. Takeshi uchiumi, a renowned scholar at Kyushu University in Japan, found that mitochondria regulate multiple different signaling and metabolic pathways, which play an important role in the cell death program. At the same time, mitochondrial function gradually declines during aging, accompanied by problems such as oxidative phosphorylation (OXPHOS) dysfunction and morphological alterations. Researchers found that beta-nicotinamide mononucleotide (NMN) intervention, can promote autophagy by repairing the function of mitochondria, elevating lysosomal function, enhancing proteostasis throughout the organism, as well as simultaneously improving 2 major aging hallmarks of mitochondrial dysfunction and proteostasis imbalance.

Studies on the anti-aging effect of beta-nicotinamide mononucleotide (nmn)

All the above studies illustrated that beta-nicotinamide mononucleotide (NMN) supplementation could effectively reverse the aging process, The problem to be faced, however, is that the majority of current clinical data on the positive efficacy of nicotinamide mononucleotide is still focused on the animal experimental stage, Although multiple additional clinical trials are in progress, what efficacy will result from its real effect in humans remains to be confirmed by data from further scientific studies in the future.

In the next article we focus on β-nicotinamide's experimental studies and the first human clinical trial of β-nicotinamide mononucleotide in China to pass ethical review;

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