Research on the application of glutathione powder

★For external use:

A randomized, double-blind, placebo-controlled clinical trial of 30 healthy Filipino women at the ages from 30 to 50 provided evidence that local use of 2% GSSG lotions had a temporary whitening effect. Patients were randomly given glutathione 2% GSSG lotion and placebo lotion twice a day for a total of 10 weeks. GSSG is superior to GSH , the latter is unstable in aqueous solutions. GSSG eventually produces GSH after absorption by the skin. Objectively assess changes in melanin index, keratin moisture content, skin smoothness, skin elasticity, and wrinkle formation. Compared to placebo, glutathione powder reduced melanin index , it is statistically significant. it also appears in the form of soaps, washed milk and creams.

Recently, chemical peeling based on glutathione powder has also emerged. Despite the lack of evidence , manufacturers claim it has improved macularity, pigmentation and skin aging.

★Oral glutathione:

A randomized, double-blind, placebo-controlled study in the Thai population looked at the effects of oral glutathione on the skin melanin index on 60 health medicine students. The subjects were randomly divided into two groups, its capsules at a dose of 500 mg/d, or a placebo for 4 weeks. During the fourth week, melanin index continued to decline in all six parts of the glutathione group, with Good tolerance.

Another open study using tablets containing it showed an improvement in the melanin index of the skin as measured by Mexameter. They use tablets instead of capsules to enhance and ensure stable bioavailance. Sub-tongue or oral pathways may improve its bioavailing more than oral tablets or capsules.

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