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Proanthocyanidins from grape seeds significantly improve NMN level

Jun 21, 2022

As an ideal NAD+ supplement, NMN has been playing an important role since it emerged in the field of anti-aging.On the one hand, more NMN anti-aging studies have been released; On the other hand, the research on NMN "good partners" has also produced many results. For example, resveratrol and PQQ are often used in combination with NMN to increase efficiency, and the protagonist of this article is "Proanthocyanidins ".


NMN and Proanthocyanidins

In 2021, the First Affiliated Hospital of Zhengzhou University published the research results in the Journal of Inflammation Research: grape seed proanthocyanidins extract (GSPE) can promote the activity of Nampt transferase, thus increasing the NMN level in the body, thereby increasing the NAD+ level and delaying cell aging.


1. What is grape seed proanthocyanidins extract (GSPE)? 

Procyanidins are natural antioxidants found in fruits, vegetables, nuts, beans, and cereals, such as grapes, apples, blueberries, raspberries, figs, almonds, walnuts, cocoa beans, etc. Among them, grape seeds are the most abundant.

Procyanidins are natural antioxidants found in fruits

Grape seed proanthocyanidins extract (GSPE) is the proanthocyanidins extracted from the whole grape seed, which is considered to be an important source of polyphenol bioflavonoids. Many studies have found that grape seed proanthocyanidins have antioxidant, anti-inflammatory, and anti-aging properties.

2. What is the use of NAMPT transferase?

NAMPT (nicotinamide phosphoribosyltransferase) is one of the key regulators of the NAD+ (nicotinamide adenine dinucleotide) metabolic pathway.

The main synthetic utilization route of NAD+ is a cycle.NAD+ will be converted into Nam (nicotinamide) after being used by the body. NAM will synthesize NMN (nicotinamide mononucleotide) through the catalysis of NAMPT transferase and then be converted into NAD+ through NAMPT transferase for reuse.

What is the use of NAMPT transferase

Therefore, after the activation of Nampt by procyanidins, it is equivalent to increasing the content of NMN in the body, so as to improve the body recession caused by aging and delay aging.

In fact, antioxidant components, including procyanidins, not only help to activate NAMPT transferase, but also enhance the activity of NAMPT transferase, playing an important role in the NAD+ recycling pathway.

3. Proanthocyanidins +NMN, enhance the anti-aging effect 

The study of Zhengzhou University not only explored the principle behind the "eye protection" of procyanidins but also confirmed the promoting relationship between procyanidins and NMN by studying the effect of procyanidins (GSPE) on the aging of retinal pigment epithelium (RPE) cells.

The aging of retinal pigment epithelium (RPE) cells is an important cause of "old eye dizziness". GSPE, by activating NAMPT transferase, increased the NAD+ level of aged mice and improved the aging of their eyes.

Proanthocyanidins +NMN, enhance anti-aging effect

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