What is semaglutide?
Obesity is a risk factor for many diseases. However, there has been no effective drug that can eliminate this risk factor for a long time. The introduction of semaglutide changed the situation. Doctors can prescribe it for people with a body mass index (BMI) greater than 30.
What does semaglutide do to your body?
Semaglutide was originally used to treat diabetes. It is a glucagon-like peptide 1 (GLP-1) receptor agonist. It can mimic its effects and reduce hunger, diet, and calories. intake, so it has an outstanding effect in weight loss.
Can you lose weight with semaglutide?
● Semaglutide for weight loss
In February 2021, the New England Journal of Medicine (NEJM) published the results of a global large-scale clinical trial showing that semaglutide has outstanding effects as a weight loss drug. Compared with the placebo group, 2.4 mg of semaglutide was injected subcutaneously every week. The malutide experimental group lost an average of 15.3 kilograms of weight. Specifically, three-quarters of people lost more than 10% of their weight, and more than one-third of the people lost more than 20% of their weight. This weight loss is a milestone. It is also the first time that humans have achieved this through drugs. Before, only surgery could do it. achieved weight loss results.
The study was published in the New England Journal of Medicine (NEJM) on November 2, 2022. In this international Phase 3a clinical trial, obese adolescents who took semaglutide once a week experienced a decrease in body mass index (BMI). increased by 16.1%, while the placebo group increased by 0.6%.
Based on the success of this clinical trial, in June 2021, the U.S. Food and Drug Administration (FDA) approved the marketing of weight loss drugs with semaglutide.
How bad are semaglutide side effects?
Common adverse reactions (incidence greater than 5%) caused by oral administration of semaglutide include nausea, vomiting, diarrhea, and constipation.
Generally, people who are sensitive to products are prone to nausea, vomiting, diarrhea, abdominal pain, indigestion, loss of appetite, etc. In the early stages, some may even develop more serious diseases such as intestinal obstruction. Another study published in JAMA showed that the rate of gastrointestinal side effects in the semaglutide treatment group was as high as 84.1%.
Some people may feel drowsy or dizzy. It usually resolves in about a week.
The gastrointestinal reaction reaches its peak in the first week, will gradually ease in about two weeks, and will basically be fully adapted to it in one month.
In some cases, you may feel your heartbeat speeding up.
The effect has nothing to do with whether there are adverse reactions, but generally speaking, the effect is better among people who have an effect and who feel nauseated in the early stage.
However, one clinical trial showed that participants treated with semaglutide regained more than 50% of their lost weight one year after stopping the drug.
Is semaglutide powder safe?
Based on the PIONEER 1-10 global clinical trial, a total of 9543 patients with type Ⅱ diabetes were enrolled. Compared with the control group, oral semaglutide reduced the glycated hemoglobin level (HbA1c) and body weight of the patients. Oral semaglutide The peptide reduces body weight by 2.0-5.0kg and has been shown to be safe and well tolerated in clinical trials.
Reference
[1]. Wilding JPH, Batterham RL, Calanna S, et al. Once-weekly semaglutide in adults with overweight or obesity. N Engl J Med 2021;384:989-1002
