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Coenzyme Q10:Cardioprotective agents

Apr 21, 2022

Coenzyme Q10 has been widely used all over the world. Many developed countries take its content in the human body as one of the important indicators to measure health.CoQ10 has been generally recognized by the medical community, in recent years, its use in cardiovascular disease has become more widespread, especially in the adjuvant treatment of heart failure has achieved satisfactory results.

Coenzyme Q10 in heart disease 

◆Coronary heart disease and myocardial infarction

There are often antecedent manifestations in the week or so before MI, such as angina pectoris that occurs at rest and during mild physical activity, with significant discomfort and exhaustion. At the time of infarction showed persistent severe compression sensation, tightness and obstruction sensation, and even knife cut like pain, which was located behind the sternum or in the left arm, with constant waves and throughout the anterior chest, with the left side as the weight.

CoQ10 can shorten the Q-T interval, decrease the VF valve, improve the heterogeneity of myocardial repolarization, and prevent recurrent VF in the early stage of AMI.

Extracted from: Northwestern medical journal, 1990; 4 CoQ10 in cardiovascular disease: a review

Coenzyme Q10

Cardioprotective agents

◆Angina Pectoris

The feeling of press and tightness and swelling behind the sternum, accompanied by marked anxiety, lasts for 3 to 5 minutes and often diverges to the left arm, shoulder, jaw, throat, back, and may also radiate to the right arm. Sometimes angina is atypical and can present as tightness, syncope, weakness, and eructation.

Medical experts conducted an 8-year open-label trial of Coenzyme Q10 in 424 patients with myocardial ischemia and angina pectoris, After 18 months, doses of cardiovascular products were tapered, with 43% of patients able to discontinue 1-3 cardiovascular products.

Extracted from: rural Chinese medicine, 1998; 26 clinical use of CoQ10


Often because of angina attacks and then lesions, myocardial extensive fibrosis, angina gradually reduces to disappear, but the manifestations of heart failure, such as tightness, edema, fatigue, etc. Arrhythmias manifested as palpitations and a proportion that never had angina, while directly manifested as heart failure and arrhythmias.

Medical experts conducted clinical trials to date (2664 patients with heart failure) and the results suggest that the efficacy and safety of CoQ10 are beyond doubt, whether for idiopathic dilated cardiomyopathy or heart failure of unknown etiology.

◆Myocardial ischemia

Many people have extensive coronary artery obstruction but have not felt angina, and some patients do not feel angina at the time of MI. Some were detected after they developed myocardial infarction. Some also had ischemic findings on their ECG and were found to be arrhythmic or had a coronary angiogram done because of a positive exercise test.

During myocardial ischemia and arrhythmia, the concentration of CoQ10 in myocardial cells will significantly decrease. Exogenous CoQ10 can enter the cell as an oxygen-free radical scavenger, which has a direct protective effect on the cell membrane and promotes the recovery of cardiac function.

Extracted from: a clinical meta-analysis, 1990; 5 CoQ10: a review of its clinical use

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