Ambroxide Powder

1. Product Introduction

Ambroxide is a high-value natural terpenoid aromatic compound synthesized from Sclareol. As an ideal synthetic substitute for natural ambergris, it delivers soft, stable and long-lasting ambergris fragrance with natural woody undertones. Due to its safe, non-irritating and hypoallergenic properties, ambroxide has become one of the most popular and recognized synthetic ambergris raw materials in the global flavor and fragrance industry.

Benefiting from abundant Salvia Sclarea plant resources, China has formed the world's largest clary sage planting and processing base. We own mature and green synthesis technology to produce high-purity ambroxide powder, ensuring stable batch quality, high purity and cost-effective factory supply.

Ambroxide powder is a natural terpenoid compound synthesized from sclareol. It is a synthetic aromatic compound commonly used in perfumes to create an ambergris-like aroma. China is rich in fragrant perilla plant resources and has become the largest Salvia sclarea planting base.

Here are some more Flavor & Fragrance Ingredients on our website, please check:Sclareol Powder, Sclareolide Powder, Rosmarinic Acid Powder, Vanillin Powder and so on.

★Process and synthesis route：
We have a very mature process for extracting sclareol from Salvia sclarea.
Using sclareol as the starting material and hydrogen peroxide as the oxidant, ambroxide is synthesized through catalysts such as heteropolyacid salts. This process is easy to operate, causes little pollution, is sustainable, and is environmentally friendly.
The advantage of this method is to reduce synthesis steps, shorten reaction time, and lower reaction temperature.

It mainly includes 3 stages:

①The oxidation stage, in which sclareol is oxidized by the oxidant to form sclareolactone;
②In the reduction stage, it is reduced by reducing agents such as LiAlH4 or KBH4 to form ambroxanediol;
③In the cyclization stage, under the action of organic acids, sulfonyl chloride compounds or Lewis acid, dehydration and cyclization generate ambroxide.

Ambroxide is one of the most critical active ingredients in natural ambergris tincture. It has a soft, long-lasting and stable ambergris aroma and a mild woody aroma.

2.Advanced Synthesis Process & Technical Advantages

    We adopt an eco-friendly, efficient and mature synthesis route with Sclareol extracted from Salvia Sclarea as the core starting material, hydrogen peroxide as the oxidant and heteropolyacid salts as catalysts. Compared with traditional processes, our technology greatly simplifies synthesis steps, shortens reaction time, lowers reaction temperature, features simple operation, low pollution and sustainable production, meeting international green chemical production standards.

The complete synthesis process is divided into three standardized stages:

• Oxidation Stage: The raw material sclareol is oxidized by oxidants to generate sclareolactone intermediate.
• Reduction Stage: The intermediate is reduced by reducing agents such as LiAlH4 or KBH4 to form ambroxanediol.
• Cyclization Stage: Under the catalysis of organic acid, sulfonyl chloride or Lewis acid, dehydration and cyclization reactions occur to generate high-purity ambroxide finished product.

1. Bulk Ambroxide powder is a prominent element in the fragrance, perfume, and essence industries.

It has a multi-layered, long-lasting, alluring fragrance.
Known for its long-lasting musky, woody and slightly sweet scent, it has excellent fixative properties and supports, enhances other notes in a fragrance, helping to extend its longevity. It is an excellent fixing agent and can be used as the base note of high-end perfumes because it can add layering, richness and warmth to the fragrance.

2. Used in cosmetics and personal care products. Its versatile scent profile allows it to blend well with a variety of other fragrance notes, making it a popular choice.

3. For aromatherapy. Its essential oil is used to reduce anxiety, stress, muscle discomfort, and sleeplessness.

4. A flavoring additive for alcoholic beverages.
5. Tobacco industry.

It has the potential to improve tobacco flavor quality, harmonize with the wood aroma of tobacco characteristics, and mask the odor of contaminants, making it particularly ideal for mixed cigarette flavor and increasing the flavor of oriental tobacco.

Reference

[1].BARTON D H R, PAREKH S I, TAYLOR D K, et al. An efficient synthesis of (-)-dodecahydro-3a, 6, 6, 9a-tetramethylnaphtho [2, 1-b] furan from (-)-sclareol[J]. Tetrahedron Letters, 1994, 35(32): 5801-5804.

[2].He, N.; Li, D.-F.; Yu, H.-W.; Ye, L.-D. Construction of an artificial microbial consortium for green production of (−)-ambroxide. ACS Sustainable Chem. Eng. 2023, 11 (5), 1939– 1948, DOI: 10.1021/acssuschemeng.2c06716.

Double polyethylene bags inside, and high-quality standard carton drum outside.

Shipping by express, air, Sea, and some special line to most Countries.