Hexamidine diisethionate salt is a synthetic antimicrobial agent that is commonly used in cleaning, hair care, and skin care products.
It significantly reduces dandruff, itching and greasy scalp.
Other common anti-dandruff agents: salicylic acid, climbazole (climbazole), zinc pyrithione (ZPT), selenium disulfide, piroctone.

Is hexamidine diisethionate safe?
It is mild in nature and less irritating. Typically, it is used in low concentrations.
Its mild antibacterial properties make it a suitable ingredient for sensitive skin. This is due to the fact that it helps reduce bacterial growth without over-irritating the skin.

| Tested Items | Specifications | Results |
| Appearance | White to off-white powder | White powder |
| IR | Should be consistent with that of the reference product | Complies |
| Qualitative Identification | Dissolve about 40 mg in 5 mL of water and add dropwise with shaking 1 mL of a 100 g/L solution of sodium chloride. Allow to stand for 5 min. An abundant,shimmering white precipitate is slowly formed. | Complies |
| HPLC | The retention time of the main peak of the test solution should be the same as that of the control solution | Complies |
| Loss on drying | ≤0.3% | 0.22% |
| Residue on ignition | ≤0.1% | 0.02% |
| Purity | ≥99.0% | 99.30% |
| Hexamidine content | 57.5-59.5% | 58.30% |
| Pb | ≤10mg/kg | ND |
| As | ≤2mg/kg | ND |
| Hg | ≤1mg/kg | ND |
| Cd | ≤5mg/kg | ND |
| Total bacterial cfu/g | ≤200cfu/g | <10 cfu/g |
| Molds and Yeast Count,cfu/g | ≤100cfu/g | <10 cfu/g |
| Thermotolerant Coliforms /g | Negative | ND |
| Staphylococcus aureus /g | Negative | ND |
| P.Aeruginosa /g | Negative | ND |

Hexamidine diisethionate can be used as a cleanser and antibacterial agent. It is used in products such as lotions and creams to keep the skin healthy. In addition to being used in shampoos and hair care products, it can also be used in hair spray products.
1. It is a new type of anti-dandruff ingredient.
Clinical studies in dermatology have shown that shampoo containing 0.1% hexamidine di(hydroxyethylsulfonic acid) salt can significantly reduce the Malassezia on the scalp area per unit area. Therefore, it also significantly improves the severity of dandruff.
2. Antibacterial, anti-acne, oil control, and anti-irritation effects.
It has broad-spectrum antibacterial and bactericidal properties, and has good bactericidal and antibacterial properties against Gram-positive and negative bacteria, as well as various molds and yeasts.
Therefore, it can be used in formulations for the treatment of acne, dermatitis and other skin diseases.






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