Product Overview

Hexamidine Diisethionate is a high-performance, water-soluble cosmetic active renowned for its exceptional multi-functional properties. Acting as a powerful yet ultra-mild water-soluble antimicrobial agent, it delivers a clinically proven "Anti-Dandruff + Anti-Acne + Sebum Regulation" triple-action mechanism.

With traditional agents like Zinc Pyrithione (ZPT) facing severe global regulatory restrictions, Hexamidine Diisethionate has emerged as the premier, compliant alternative for modern clean-beauty formulations. Because it is highly stable, inherently mild, and non-irritating, it is perfect for leave-on scalp serums, acne lotions, and products targeting sensitive, compromised skin barriers.

Hexamidine Diisethionate

Peer Comparison: The Next-Gen Anti-Dandruff Alternative

Compared to traditional anti-dandruff and antimicrobial agents (such as Salicylic Acid, Climbazole, Zinc Pyrithione [ZPT], Selenium Disulfide, and Piroctone Olamine), Hexamidine Diisethionate offers a distinct dual advantage: Uncompromising Broad-Spectrum Efficacy paired with Exceptional Skin Tolerance. It effectively limits microbial growth without stripping or over-irritating the skin barrier.

Technical Specifications (Certificate of Analysis)

Tested Items	Specifications	Results
Appearance	White to off-white powder	White powder
IR	Should be consistent with that of the reference product	Complies
Qualitative Identification	Dissolve about 40 mg in 5 mL of water and add dropwise with shaking 1 mL of a 100 g/L solution of sodium chloride. Allow to stand for 5 min. An abundant,shimmering white precipitate is slowly formed.	Complies
HPLC	The retention time of the main peak of the test solution should be the same as that of the control solution	Complies
Loss on drying	≤0.3%	0.22%
Residue on ignition	≤0.1%	0.02%
Purity	≥99.0%	99.30%
Hexamidine content	57.5-59.5%	58.30%
Pb	≤10mg/kg	ND
As	≤2mg/kg	ND
Hg	≤1mg/kg	ND
Cd	≤5mg/kg	ND
Total bacterial cfu/g	≤200cfu/g	<10 cfu/g
Molds and Yeast Count,cfu/g	≤100cfu/g	<10 cfu/g
Thermotolerant Coliforms /g	Negative	ND
Staphylococcus aureus /g	Negative	ND
P.Aeruginosa /g	Negative	ND

Core Benefits & Cosmetic Efficacy

1. Targeted Anti-Dandruff & Scalp Homeostasis

Dermatological clinical studies reveal that a shampoo formulated with just 0.1% Hexamidine Diisethionate drastically reduces the population density of Malassezia (the primary fungus responsible for dandruff) per unit area. It relieves scalp pruritus (itching), eliminates visible flaking, and calms redness.

2. Broad-Spectrum Antimicrobial & Anti-Acne Action

Exhibits excellent, powerful bactericidal and fungicidal activity against both Gram-positive and Gram-negative bacteria, molds, and yeasts. It highly effectively targets Cutibacterium acnes (C. acnes), making it a stellar ingredient for purifying acne-prone skin and preventing breakouts.

3. Precision Sebum & Oil Control

By rebalancing the microflora of greasy scalps and facial skin, it naturally regulates excess sebum secretion. This helps prevent the pore blockages that lead to comedones, blackheads, and folliculitis.

4. Non-Sensitizing & Mild Nature

Unlike harsh antibacterial agents that trigger skin purging or dryness, this water-soluble salt functions smoothly at low concentrations, making it safe and comforting for sensitive, reactive, or compromised skin types.

Formulator's Application Guide

Versatile Product Categories

Hair & Scalp Care: Anti-dandruff shampoos, scalp-soothing conditioners, leave-in hair sprays, and hair tonics.
Skin & Body Care: Anti-acne creams, purifying facial cleansers, clarifying toners, and restorative lotions.

Formulation & Solubility Notes

Highly water-soluble and stable across typical cosmetic pH ranges. It integrates easily into clear aqueous systems, hydrogels, emulsions, and surfactant-based formulas without affecting transparency or texture. Recommended active concentration typically ranges from 0.05% to 0.1%.

Hexamidine diisethionate