Hydroxypinacolone Retinoate HPR is a third-generation vitamin A derivative, an ester with retinoic acid as the substrate.
It is an ideal alternative to retinoic acid.
Advantages:
1. It has the excellent beauty effects of retinol, but is non-irritating and stable in nature.
2. HPR acts directly on the receptor protein to exert its effect.
Vitamin A Series Products Available: Vitamin A Derivatives and Retinoic Acid Derivatives
Retinaldehyde
Retinoic acid
Retinyl acetate
Retinyl propionate
Retinyl linoleate
Retinyl retinoate
Retinyl palmitate
Hydroxypinacolone retinoate
Retinyl trimethylsilane
Retinol/saccharomyces polypeptide
Methoxy PEG-12 retinamide
Tocopheryl retinoate
Is hydroxypinacolone retinoate better than retinol?
|
Feature |
Hydroxypinacolone Retinoate (HPR) |
Retinol |
|
Potency |
More potent, directly binds to retinoid receptors |
Weaker, requires conversion to retinoic acid |
|
Conversion Needed |
No conversion needed (active form) |
Must convert to retinoic acid in the skin |
|
Irritation |
Lower risk of irritation, more tolerable |
Higher risk of irritation, redness, and peeling |
|
Stability |
More stable in formulations |
Less stable, degrades faster |
|
Effectiveness |
Faster and more direct effects on wrinkles, pigmentation, and collagen production |
Slower effects due to conversion process |


| Item | Specification | Results |
| Appearance | Yellow crystal | Conform |
| Odor &Taste | Characteristic | Conform |
| Assay | ≥99% | 99.83% |
| Total impurities | ≤1.0% | 0.17% |
| Single impurity | <0.5% | 0.09% |
| Retonic acid residue | ≤100ppm | Conform |
| Loss on Drying | ≤0.5% | 0.30% |
| Water content | ≤0.1% | 0.04% |
| Scorch residue | ≤0.1% | 0.06% |
| Heavy Metals | ≤10 ppm | Conform |
| As | ≤0.5 ppm | Conform |
| Cd | ≤1.0 ppm | Conform |
| Pb | ≤1.0 ppm | Conform |
| Hg | ≤0.5 ppm | Conform |
| Pd | ≤0.5 ppm | Conform |
| TotalPlate Count | ≤1000 cfu/g | Conform |
| Total Yeast &Mold | ≤100 cfu/g | Conform |
| E.Coli | Negative | Absent |
| Salmonella | Negative | Absent/25g |
| Staphylococcus | Negative | Absent/25g |
| Test Result: This product passes the test | ||

1. Good anti-aging performance. After using HPR (2%) for two weeks, fine lines and wrinkles were significantly reduced.
2. Excellent function of regulating the metabolism of the epidermis and stratum corneum.
3. Regulate sebum secretion.
4. Lighten pigments, whiten and remove spots.
5. Improve skin quality and beauty effects. Hydroxypinacolone Retinoate HPR can promote cell differentiation and renewal, and improve skin roughness.






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