The estrone powder is white crystalline powder, soluble in ethanol but insoluble in water. Commonly used methods for detecting estrone include high performance liquid chromatography and gas chromatography.
Around the 1930s, chemists began to study sex hormones. Butenandt first extracted and isolated estrone from the urine of pregnant women and determined that it was a steroid substance.
Estrone is a weak female steroidal sex hormone that together with estradiol and estriol constitutes the three major endogenous estrogens.
It is a primitive hormone secreted by the ovaries of female animals, mainly secreted by the gonads, and a small part is the conversion of androgens from the adrenal glands by adipose tissue.
COA
| Items | Specifications | Results |
| Ref standard | According with the USP39 | |
| Assay | 97%-103% | 98.60% |
| Appearance | White or white like crystalline powder | Conforms |
| Identification | Requirements standard | Conforms |
| Loss on drying | ≤0.5% | 0.13% |
| Clarity of solution | The solution is clear | Conforms |
| Specific optical rotation | +158°~+165° | +163° |
| Residue on ignition | ≤0.5% | 0.16% |
| Any other impurities | ≤0.5% | 0.15% |
| Total impurities | ≤1.0% | 0.40% |
| Conclusion: | The product conforms to the USP39 | |
1. Estrone can promote the development and maturity of female secondary sexual characteristics, maintain normal menstrual cycles and pregnancy processes, protect the cardiovascular system, and resist osteoporosis.
Estrone works mainly by binding to estrogen receptors and is mainly used to treat uterine hypoplasia, menstrual disorders, etc.
Estrone can also be used to treat ovarian insufficiency, amenorrhea, functional uterine bleeding, breast cancer, etc.
2. Estrone can be used in combination with progesterone to achieve the purpose of contraception by inhibiting the secretion of gonadotropins from the pituitary gland and blocking ovulation.
3. For the treatment of menopausal syndrome.
Estrone powder is an important pharmaceutical intermediate that can be used to synthesize ethinyl estradiol or estradiol derivatives.
The research and development of estrone laid the foundation for the pharmacology and clinical application of estrogen, and also promoted the discovery and synthesis of other sex hormones.
It is used in biochemical research and plays a vital role in medicine.
Estrone is available as injections, tablets, patches, and gels.Oral estrone tablets have low bioavailability, so subcutaneous injection or transdermal administration is common.
Reference
[1].Pauwels S, Antonio L, Jans I, et al.. Sensitive routine liquid chromatography–tandem mass spectrometry method for serum estradiol and estrone without derivatization. Anal Bioanal Chem. 2013;405(26):8569-8577.
[2].Lephart E. A review of the role of estrogen in dermal aging and facial attractiveness in women. J Cosmet Dermatol. 2018;17(3):282-288. doi:10.1111/jocd.12508
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