PRODUCT OVERVIEW & BIOCHEMICAL SIGNIFICANCE
Vitamin B12 (Cobalamin) is a unique, cobalt-containing water-soluble micronutrient essential for cellular metabolism, red blood cell maturation, and neurological health. In the human body, B12 functions as an indispensable co-factor for two critical enzymes:
Methionine Synthase: Drives the remethylation of homocysteine to methionine, supporting one-carbon folate metabolism, DNA synthesis, and cellular methylation.
Methylmalonyl-CoA Mutase: Directs the conversion of methylmalonyl-CoA to succinyl-CoA for hemoglobin synthesis and the generation of energy via the citric acid cycle.
Because B12 is synthesized exclusively by microorganisms and concentrated almost entirely in animal-derived foods (meat, poultry, eggs, fish, and dairy), strict vegetarians, vegans, the elderly (due to reduced gastric intrinsic factor), and post-bariatric surgery patients face high risks of deficiency. Our pharmaceutical-grade Vitamin B12 meets stringent USP 42 monographs, delivering certified potency, low impurity profiles, and superior stability for dietary supplements and clinical nutrition.
OEM ODM Available, Other forms of vitamin B12 are also available
![]() |
![]() |



|
Batch Quantity |
14.5kg |
According as |
USP 42and in house standard |
|
Test items |
Specifications |
Results |
Test methods |
|
Characters |
Dark red crystals or amorphous or crystalline red Powder. |
Complies |
Visual method |
|
Identification A |
UV: The absorption spectrum exhibits maxima at 278±1nm,361±1 nm,and550±2nm. |
Complies |
USP monograph |
|
A36I nm/A278nm : 1.70〜1.90 A36I nrn,A550nm : 3.15'~^3,40 |
1.85 3.26 |
USP monograph |
|
|
Identification B |
Cobalt:Meets USP requirements |
Complies |
USP monograph |
|
Identification C |
HPLC.The retention time of the major peak of the sample solution corresponds to that of the standard solution. |
Complies |
USP monograph |
|
Loss on drying |
≤10.0% |
2.6% |
USP monograph |
|
Assay |
97.0% 〜102.0% |
99.3% |
USP monograph |
|
Related substances |
Total impurities ≤3.0 % |
1.2% |
USP monograph |
|
7 P ,8 0 -Lactocyanocobalamin ≤ 1.0 % |
0.6% |
||
|
34-Methylcyanocobalamin ≤ 2.0 % |
0.1% |
||
|
8-Epi-cyanocobalamin USP ≤ 1.0% |
0.1% |
||
|
Any other unidentified impurity and 50-Carboxycyanocobalamin> 32- Carboxycyanocobalamin ≤0.5% |
<0.5% |
||
|
Acetone |
≤5000ppm |
203ppm |
In house/(GC) SOP-QC-001-04-05 |
|
The total aerobic microbial count |
≤1000 cfu/g |
<10cfu/g |
ChP <1105> |
|
The total combined yeasts/mould count |
≤100 cfu/g |
<10cfu/g |
ChP <1105> |
| Conclusion: |
The product complies with the specifications |
||
CORE HEALTH BENEFITS & PHARMACOLOGICAL ACTIONS
Prevention of Megaloblastic Anemia & Erythropoiesis: Vitamin B12 is essential for bone marrow erythroblast maturation. Adequate levels prevent impaired nuclear maturation and abnormal enlargement of red blood cells, ensuring efficient oxygen delivery throughout peripheral tissues.
Myelin Sheath Maintenance & Neurological Integrity: Supports the biosynthesis of fatty acids in the myelin sheaths that insulate nerve fibers. B12 supplementation relieves peripheral neuropathy, decreases tingling/numbness in extremities, and aids post-injury nerve repair.
Homocysteine Regulation & Cardiovascular Protection: By fueling the remethylation of homocysteine to methionine, B12 prevents hyperhomocysteinemia, an independent risk factor for arterial endothelial damage, platelet aggregation, and atherosclerosis.
Cognitive Vitality & Mood Regulation: Acts as a required coenzyme in the production of monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Helps reduce brain fog, relieve irritability and mild depressive mood, and support long-term memory in aging populations.
Cellular Energy & Fatigue Reduction: Facilitates mitochondrial lipid and protein metabolism into succinyl-CoA, ensuring seamless cellular ATP production and mitigating chronic physical exhaustion.
Oral Mucosal Integrity & Keratin Health: Maintains normal cellular turnover in tongue papillae and mucosal linings, preventing recurrent mouth ulcers and glossitis. Promotes healthy microcirculation to skin tissue and nail matrices.
COMMERCIAL APPLICATIONS & DELIVERY DOSAGE FORMS
Sublingual Tablets & Lozenges: Formulated for transmucosal absorption, directly bypassing potential gastrointestinal absorption barriers (lack of intrinsic factor or hypochlorhydria).
Dietary Supplement Capsules & Multivitamin Premixes: Available in pure API or safe, homogenous 1% triturations on carrier bases (DCP/Mannitol) for seamless industrial capsule blending and tablet compression.
Liquid Droppers & Oral Sprays: High-stability liquid formulations with clean flavor-masking profiles for pediatric, prenatal, and elderly users.
Specialized Sports & Hangover Recovery Drinks: Blended with B-Complex vitamins, electrolytes, and Taurine for energy renewal and liver detoxification support.
FACILITY CAPACITY, QUALITY CONTROL & PACKAGING
Manufacturing Equipment & Technical Capacity:
Multi-functional extraction workshop: 6 sets of 6 m3 extraction units.
Chemical reaction & synthesis units: 4 sets of 5 m3 high-precision reactors.
Concentration units: 7 sets of external circulation evaporation units (1,500 kg/h capacity).
Chromatography purification: 4 sets of 2 m3 high-efficiency chromatographic columns.
Spray drying: 1 specialized spray-drying tower (250 kg/h evaporation capacity).
Solvent recovery: 1 high-efficiency alcohol rectifying system (2,000 kg/h capacity).
Clean Area: 400 m2 of dedicated Class D (100,000-grade) cleanroom workshop operating under strict cGMP standards.
Packaging & Shipping Specifications:
Bulk Packaging: Inner sterile double-polyethylene (PE) food-grade bags, outer air-tight aluminum foil barrier pouch, sealed in export-standard carton fiber drums (1 kg, 5 kg, 20 kg, 25 kg).
Storage: Keep tightly closed in original packaging; store in a dry, cool, dark, and well-ventilated area away from strong light and moisture.
Global Logistics: Full air freight, express (courier), sea freight, and dedicated door-to-door lines with complete export documentation (COA, Non-GMO, BSE/TSE-Free, Halal, Kosher).

1. Participate in DNA synthesis: It can promote the synthesis and stability of DNA and maintain the normal development and differentiation of blood cells.
2. Maintain nervous system function: It can promote the normal operation of brain nerve cells and maintain the stability of nervous system function.
3. Improve mental state: Closely related to the normal function of the nervous system, supplementing enough vitamin B12 can improve mental state and relieve anxiety, depression and other emotional problems.
4. Relieve fatigue and increase energy levels: It can help the body utilize nutrients such as carbohydrates, fats and proteins to provide energy and relieve fatigue.
5. Promote immune system function: It can enhance the function of the human immune system and help prevent infections, inflammation and other diseases.
6. Prevention and treatment of anemia: Lack of vitamin B12 can lead to megaloblastic anemia, so the intake of B12 can prevent and treat anemia.
7. Improve memory and cognitive function: participate in the normal function of nerve cells, help improve memory and cognitive function, and prevent cognitive decline and Alzheimer's disease.
8. Promote red blood cell production: Promote the production of red blood cells in the bone marrow, helping to prevent and treat anemia. It helps maintain normal levels of red blood cell number and function in the blood.
9. Maintain oral health: It can promote the normal growth of tongue papilla, maintain the health of oral mucosa, and prevent oral ulcers and oral inflammation.

1. Skin-related problems: It also affects the health of the skin. To improve skin texture and relieve skin problems such as dryness and inflammation.
Double polyethylene bags inside, and high-quality standard carton drum outside.
2. Nervous system diseases: Play a key role in the normal function of the nervous system. Therefore, it can be used to treat some neurological diseases, such as peripheral neuropathy, spinal cord injury, multiple sclerosis, etc.
4. Alzheimer's disease: Participates in the normal function of nerve cells and helps improve memory and cognitive functions. Therefore, it has been studied for the prevention and treatment of Alzheimer's disease.
5. Nutritional supplement: For certain groups of people, such as vegetarians, strict vegetarians, gastrointestinal surgery patients, etc., the intake of vitamin B12 may be insufficient. In this case, the body's needs for this nutrient can be met through B12 supplementation.
6. Nerve pain: Helps reduce pain and improve neuralgia symptoms by normalizing the function of the nervous system.
7. Cataracts: Moderate intake may play a certain role in preventing or slowing down the development of cataracts.
8. Osteoporosis: May help improve bone density and prevent osteoporosis.
Shipping by express, air, Sea, and some special line to most Countries

We have our own plant extraction workshop and OEM aseptic workshop.
The company has strong technical force and experienced production staff. The company has 6 sets of 6m3 modern multi-functional extraction equipment, 4 sets of 5m3 reactors, 7 sets of external circulation evaporation and concentration equipment with an evaporation capacity of 1500kg/h, 4 sets of chromatographic columns with a volume of 2m3, and an evaporation capacity of 250kg/h spray One set of drying tower, one set of rectifying alcohol 2000kg/h rectifying tower, 400㎡ of Class D clean area.
The company not only has advanced technology and professional equipment, but also has a sound system and strict and professional standards in raw material selection and procurement, ensuring a complete and comprehensive quality control system from raw material procurement to product delivery.







Hot Tags: Vitamin B12 Cyanocobalamin Powder, China Vitamin B12 Cyanocobalamin Powder manufacturers, suppliers, factory, Tocopherol CAS 2074 53 5, vitamin a palmitate supplement, Vitamin B9, Tocopherol Powder, best vitamin b complex powder, Vitamin c tablets


