UDCA

1. Product Introduction

Ursodeoxycholic Acid (UDCA) is a hydrophilic, non-cytotoxic natural bile acid and a stereoisomer of chenodeoxycholic acid. Featuring excellent choleretic, hepatoprotective, antioxidant and immunomodulatory properties, UDCA has become a classic and essential clinical drug for the treatment of various hepatobiliary diseases. It effectively promotes bile acid secretion, reduces cholesterol saturation in bile, inhibits endogenous cholesterol synthesis, and assists in dissolving cholesterol gallstones.

With decades of market verification, UDCA is the only FDA-approved drug for cholestatic liver disease, especially for primary biliary cholangitis. Its safety, stability and efficacy have been fully recognized by global clinical medicine. We supply high-purity UDCA raw material powder that fully complies with EP8 pharmacopoeia standards, with complete test reports and stable batch quality.

2. Core Pharmacological Functions & Efficacy

• Anti-cholestasis & Hepatoprotection: As a non-toxic hydrophilic bile acid, UDCA activates calcium ions, protein kinase C and cleavage-active protein kinase to enhance the secretory function of cholestatic hepatocytes. It effectively reduces the concentration of toxic endogenous hydrophobic bile acids in blood and liver tissues, relieving cholestasis and protecting liver cells.
• Dissolve & Prevent Gallstones: UDCA significantly reduces cholesterol saturation in bile, promoting the dissolution and shedding of cholesterol gallstones. Meanwhile, it inhibits the activity of hydroxymethylglutaryl-CoA, lowering hepatic cholesterol synthesis and bile cholesterol secretion to prevent recurrent gallstone formation.
• Anti-inflammatory & Immunomodulatory: It exerts reliable anti-inflammatory effects on liver and colon tissues, regulates body immune response, and reduces chronic inflammatory damage to hepatobiliary system.
• Novel Anti-viral Potential (Anti-COVID-19): According to 2022 research from the University of Cambridge, UDCA can specifically block ACE2 receptors - the key cell entry channel for SARS-CoV-2. Cell and animal experiments have verified that UDCA effectively inhibits virus adhesion and infection, providing new research directions for antiviral intervention.

3. Clinical Application & Product Formulations

Ursodeoxycholic Acid is a mature and first-line clinical drug for hepatobiliary diseases, widely used in the treatment of gallstones, cholecystitis, cholestatic liver disease and biliary tract inflammation. It is currently theonly FDA-approved therapeutic drug for primary biliary cholangitis with proven long-term safety and clinical stability.

Main commercial dosage forms include UDCA capsules and tablets, occupying a mature market share: UDCA capsules account for 74.61% of the market, and UDCA tablets account for 20.58%. We provide high-purity UDCA raw material powder for pharmaceutical synthesis, finished drug preparation and medical research.

1.Prevent COVID-19
In 2022, the research team of Fotios Sampaziotis at the University of Cambridge in the UK discovered that UDCA, a drug for treating liver disease, can block ACE2 receptors and thereby block infection by the new coronavirus. The results of cell experiments and animal experiments have verified the feasibility of the theory.
ACE2 is widely present on the cell membranes of various organs in the human body and is the main "channel" used by the new coronavirus to enter and infect cells.

2. Ursodeoxycholic acid can reduce the saturation of cholesterol in bile, thereby dissolving and shedding cholesterol in stones. In addition, limiting the activity of hydroxy-methylglutaryl coenzyme reduces cholesterol synthesis and secretion to prevent and dissolve cholesterol stones.

3. Ursodeoxycholic Acid is a non-toxic hydrophilic cholic acid. By activating calcium ions, protein kinase C, and cleavage-active protein kinase, it enhances the secretion capacity of cholestatic hepatocytes, thereby reducing the concentration of endogenous hydrophobic cholic acid in blood and liver cells to achieve anti-cholestasis effects.

Ursodeoxycholic Acid Capsules and Tablets
It is an important clinical drug in the treatment of gallstones, cholecystitis, liver disease and biliary tract disease.
UDCA is currently the only drug approved by the FDA for the treatment of cholestatic liver disease, especially primary biliary cholangitis. Ursodeoxycholic acid capsules are the main preparations sold, accounting for 74.61% of the market, and ursodeoxycholic acid tablets account for 20.58% of the market. This drug is not a new drug. It has been on the market for many years and its safety and stability are guaranteed.

REFERENCE

[1].Ward JBJ, Lajczak NK, Kelly OB, O'Dwyer AM, Giddam AK, Ní Gabhann J, Franco P, Tambuwala MM, Jefferies CA, Keely S, Roda A, Keely SJ. Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon. Am J Physiol Gastrointest Liver Physiol. 2017 Jun 01;312(6):G550-G558.

[2].Makino I, Tanaka H. From a choleretic to an immunomodulator: historical review of ursodeoxycholic acid as a medicament. J Gastroenterol Hepatol. 1998 Jun;13(6):659-64.

FAQ

Q1: Can I get free Ursodeoxycholic Acid powder samples?

A: Yes, we provide free product samples. Customers only need to bear the corresponding shipping cost.

Q2: What are your payment methods and order procedures?

A: We will send a Proforma Invoice with detailed bank information after order confirmation. We accept multiple payment methods, including T/T, Western Union, PayPal and Alibaba Escrow.

Q3: How to confirm product quality before placing a formal order?

A: You can test our free samples first. Complete COA documents are available. We can also customize products strictly according to your required specifications.

Q4: What is your MOQ?

A: The standard MOQ is 1kg. Small trial orders of 100g are acceptable with full sample fee prepayment.

Q5: What is your delivery cycle?

A: Goods will be delivered within 3-5 working days after payment confirmation (excluding Chinese holidays).

Q6: Do you offer bulk discount?

A: Yes, we provide tiered pricing, and larger purchase quantities enjoy more favorable wholesale prices.