Pregnenolone Powder (PREG) is mainly synthesized in the adrenal mitochondria, with small amounts of PREG produced, synthesized and metabolized in the gonads and brain.
Once synthesized, pregnenolone can be converted into DHEA (dehydroepiandrosterone) or progesterone. DHEA acts as a precursor compound to androgens and estrogens.
Levels of natural pregnenolone are high in young men and women, peaking around age 30 and gradually declining thereafter.
Pregnenolone PREG has potent activity as a neurosteroid.
The anti-inflammatory and anti-fatigue properties of pregnenolone have been recognized since the 1930s.
COA
| Item | Specification | Results |
| Assay | 98.5~101.5% | 99.6% |
| Appearance | White crystalline powder | White crystalline powder |
| Melting range | 180.0~193.0℃ | 181.0~190.5℃ |
| Identification | A:IR B:TLC | Conforms |
| Specific rotation | +25.5 °~ +31.5 ° | +28.0° |
| Loss on drying | ≤0.40% | 0.11% |
| Related substances | Individual impurity≤ 0.5% | 0.24% |
| Total impurities≤ 1.0% | 0.4% | |
| Conclusion | The product conforms to the enterprise standard | |
1. Pregnenolone powder is one of the raw materials for the production of many hormones. It is a precursor to many important hormones such as dehydroepiandrosterone (DHEA), progesterone, estrogens, and glucocorticoids.
As pregnenolone levels decrease, so will DHEA and estrogen.
PREG is metabolized to progesterone (PROG) and further converted to allopregesterone (ALLO-P)
2. Pregnenolone helps regulate sleep and mood, and it has been studied to treat cognitive and behavioral symptoms associated with schizophrenia and other mood disorders. Pregnenolone is another option for stress relief supplements.
3. Pregnenolone has been shown to enhance learning and memory in animal models at physiologically relevant concentrations.
Pregnenolone protects against NDMA receptor agonist-induced learning and memory deficits.
4. PREG and its derivatives can act as a buffer against age-related hormonal decline, reduce the risk of dementia, and promote the growth and survival of brain cells.
5. Studies have pointed out that in addition to promoting the synthesis of steroid hormones, pregnenolone, as a neurosteroid, pregnenolone sulfate can act as a negative regulator of GABA.
6. In addition, pregnenolone has also been shown to increase acetylcholine levels.
1. Bulk pregnenolone powder can be used as a raw material and precursor for many hormones
2. Pregnenolone supplementation supports optimal hormone levels and promotes healthy aging.
Reference
[1]. Wang M, Seippel L, Purdy RH, Backstrom T. Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one. J Clin Endocrinol Metab 1996;81:1076-82.
[2]. Vallée M., Mayo W., and Le Moal M. (2001) Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. Brain Res. Rev. 37, 301–312 10.1016/S0165-0173(01)00135-7.
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