Honokiol is one of the main active ingredients of Magnolia officinalis Rehd. et Wils. or, and its content has become an important indicator of the quality of Magnolia officinalis medicinal materials. Honokiol has antibacterial, antiviral, antitumor, anti-inflammatory, antioxidant and anti-aging effects, and has obvious pharmacological activities on the digestive, nervous, cardiovascular and respiratory systems. Honokiol is a hydrophobic biphenol compound that is difficult to dissolve in water. It is poorly absorbed in the gastrointestinal tract after oral administration. More than half of the oral dose of drugs is directly excreted from the body through the gastrointestinal tract, and more than 40% of the drugs are excreted after metabolism.
Among them, honokiol is best absorbed in the duodenum. The honokiol in the magnolia inclusion complex has no specific absorption site in the intestine and does not require the participation of a specific carrier. Since honokiol is a biphenol structure and has strong fat solubility, it is believed that honokiol is absorbed through the passive diffusion pathway of lipids.
