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The main mechanism of GHK-Cu Copper Peptide Powder for anti-oxidation

Jul 07, 2021

ProCyte has developed Tricomin and Iamin for hair rebirth series brands. In 1999, the company established the NEOVA brand, applying GHK-Cu copper peptide powder to anti-aging and restorative beauty products for the first time. The discovery and purification of this ingredient has also become NEOVA's global exclusive patent. its Face cream is one of the most classic products, which is often recommended by dermatologists and plastic surgeons.

△NEOVA GHK-Cu Copper Peptide Powder Cream

In order to deeply investigate the physiological activity and mechanism of GHK-Cu copper peptide powder in anti-oxidation, repair and other aspects, Dr. Pelt has conducted many genetic and cellular studies on this ingredient. In 2012, Dr. Pelt published an article briefly describing the main mechanism of blue copper peptides' antioxidant activity, which is the superoxide dismutase (SOD) activity stimulated by copper. In 2018, he mentioned in another article published in 2018 that blue copper peptide has an effect on the gene expression of skin regenerating cells, and listed the genes that tripeptide-1 may have an effect on.

△Tripeptide-1 affects DNA repair genes and the percentage of affected genes (screenshot from related literature)

Regarding the mechanism of action of GHK-Cu copper peptide powder, it is currently certain that copper is the most critical role among them. According to Joshua Zeichner, an expert at Mount Sinai Dermatology Center in New York, copper plays an important role in protecting skin health. It can help build collagen and elastin, and stimulate the skin to produce hyaluronic acid, which is important for strengthening the skin.

The related literature believes that the effect of blue copper peptide needs to maintain the coordination state of copper ions and tripeptides, but acidic substances easily release the copper ions in the complex, which will reduce the activity of SOD, while reducing the antioxidant effect . Therefore, it is extremely important to ensure the structural integrity of blue copper peptides in applications. At present, it need can be achieved through carrier technologies such as liposome encapsulation, which is also the main research direction in the future.


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