1. Product Introduction
Febrifugine is a rare natural quinazolinone alkaloid mainly isolated and extracted from the traditional Chinese medicinal herb Dichroa febrifuga, and it is also found in garden plant hydrangea. Early laboratory synthetic research revised the initially reported stereochemical structure of febrifugine, confirming its accurate molecular configuration.
Febrifugine possesses outstanding natural antimalarial activity, as well as significant antipyretic and emetic effects. Its synthetic halogenated derivative, halofuginone, is widely applied in veterinary medicine as a high-efficiency coccidiostat. In addition, multiple artificially modified febrifugine derivatives have been developed for the adjuvant treatment of malaria, cancer, tissue fibrosis and various inflammatory diseases, showing great research and industrial application value in biomedicine.
2. Basic Physical & Chemical Specifications
| Product: | Febrifugine/Dichroa Febrifuga powder | ||
| CAS: | 24159-07-7 | ||
| Molecular formula: | C16H19N3O3 | ||
| Molecular weight: | 301.344 | ||
| Accurate Mass: | 301.142642 | ||
| Percentage Composition: | C 63.77%; H 6.35%; N 13.94%; O 15.93% | ||
| Physical Description: | White crystal | ||
| Biological Source: | Dichroa febrifuga | ||
| Biological Use/Importance: | Shows high degree of antimalarial activity,antipyretic and emetic activities | ||
| Melting Point: | Mp 139-140℃. Mp 154-156℃(dimorph.) | ||
| Optical Rotation: | [α]25D +6 (c, 0.5 in CHCl3) (c, 0.5 in EtOH) | ||
| Partition Coefficient (Calculated): | Log P-0.33 (calc) | ||
| Assay: | ≥ 98% | ||
| USES: | Used for content determination of/identification/pharmacology experiment, etc | ||
| Storage conditions: | 2-8°C refrigerated, sealed, avoid light | ||
| The period of validity: | 2 years | ||
| Availability: | The spot |

3. Complete COA Quality Test Report
Our Febrifugine raw material adopts high-standard purification technology, with ultra-high purity, extremely low impurity content and qualified microbial safety indicators, fully compliant with biomedical experimental and pharmaceutical grade standards.
| Item | Standard | Test Results | |
Identification | A.H-NMR:Comply with the structure | Complies | |
B.LC-MS:Comply with the structure | Complies | ||
| C.The IR spectrum of sample should be identical with that of reference standard; | Complies | ||
D.HPLC-ESI-MS The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. | Complies | ||
| Crystallinity | meets the requirements. | Complies | |
| Loss on drying | ≤2.0% | 0.19% | |
| Heavy metals | ≤10 ppm <10ppm | ||
| Water | ≤1.0% | 0.1% | |
| Sulphated ash | ≤0.5%, determined on 1.0 g. | 0.009% | |
| Related substances | Unspecified impurities: for each impurity | ≤0.10% | <0.10% |
Total Impurity | ≤0.5% | 0.18% | |
| Purity | ≥99.0% | 99.7% | |
| Assay | 99.0%~101.0% (anhydrous substance). | 99.8% | |
Microbiological Analysis | |||
| Total plate count | ≤1000cfu/g | Complies | |
| Yeast and Moulds | ≤100cfu/g | Complies | |
| E. Coli. | Absent | Negative | |
| Salmonella | Absent | Negative | |
| S.aureus | Absent | Negative | |
| Storage | Preserve in well-closed, light-resistant and airtight containers. | Complies | |

4. Core Biological Functions & Efficacy
Febrifugine is a high-value natural bioactive alkaloid with multiple pharmacological activities, widely used in biomedical research and drug development:
1. High-Efficiency Antimalarial Activity
It has significant inhibitory and killing effects on malaria parasites, with high antimalarial activity, which is the core characteristic pharmacological effect of febrifugine, providing an important natural active template for antimalarial drug research and development.
2. Antipyretic & Emetic Regulation
It has obvious antipyretic effect, which can effectively relieve persistent fever symptoms. Meanwhile, it has regulatory effect on digestive tract reaction and improves adverse symptoms such as vomiting.
3. Anti-Inflammatory & Anti-Fibrosis
Febrifugine and its synthetic derivatives can effectively inhibit inflammatory response, reduce tissue inflammation damage, and block tissue fibrosis progression, with good application potential in the treatment of chronic inflammatory diseases and fibrotic lesions.
4. Anti-Tumor Biological Activity
Related studies have confirmed that febrifugine derivatives have targeted inhibitory effects on a variety of tumor cells, which can interfere with tumor cell proliferation and metastasis, and is an important raw material for anti-tumor drug screening and research.
5. Veterinary Antiparasitic Effect
Its halogenated derivative halofuginone is a classic veterinary coccidiostat, which is widely used in livestock and poultry breeding to prevent and treat coccidiosis and ensure breeding safety.
5. Main Applications
1. Biomedical Scientific Research
Used for standard substance identification, content determination, pharmacological mechanism research and experimental teaching, serving as a core standard raw material for malaria, inflammation, fibrosis and tumor-related biomedical experiments.
2. Pharmaceutical Development
As a key lead compound for the development of new antimalarial, anti-inflammatory, anti-fibrosis and anti-tumor drugs, it provides an important molecular basis for new drug synthesis and modification.
3. Veterinary Medicine Industry
Its derivatives are widely used in veterinary clinical antiparasitic and coccidiosis prevention and treatment, with stable curative effect and high safety.
6. Product Advantages
Ultra-High Purity: The actual test purity is up to 99.7%, with extremely low single and total impurities, meeting high-end experimental and pharmaceutical grade standards.
Complete Structural Activity: Strictly screened natural crystal structure, complete molecular activity, stable pharmacological effect, consistent with standard reference substance structure.
Strict Safety Control: Ultra-low heavy metals, moisture and ash content, sterile microbial indicators, safe and reliable for biomedical research and drug development.
Adequate Stock Supply: Long-term stable spot supply, supporting small trial orders and large-batch bulk orders, fast delivery.



7. Packaging & Storage
Standard Packaging Specifications: 10g/bag, 1kg/bag, 25kg/drum. Customized packaging is available according to customer requirements.
Professional Storage Conditions: Sealed, light-proof, airtight packaging, stored in a cool and dry environment at 2-8°C, away from high temperature and strong light.
Shelf Life: 24 months under standardized sealed storage conditions.

8. Quality Certificate
All products are equipped with complete COA test reports, structural identification reports and qualification certificates. We support authoritative third-party testing, with traceable product quality and compliant indicators.
9. Transportation
Support global multi-channel transportation including international express, air freight and sea freight. Adopt professional low-temperature sealed packaging for special biochemical raw materials to ensure product activity and stability during transportation.
10. FAQ
Q1: Can I get free product samples?
A: Yes, we can provide free febrifugine samples. Customers only need to bear the corresponding freight cost.
Q2: What payment methods are supported for orders?
A: After order confirmation, we will issue a proforma invoice with official bank information. We support T/T, Western Union, Paypal and Alibaba Escrow payment methods for safe and convenient transactions.
Q3: How to confirm product quality before bulk ordering?
A: You can apply for free samples for quality testing and verification. We can also customize products strictly according to your personalized specifications and technical requirements.
Q4: What is your MOQ?
A: The standard MOQ is 1kg. For trial cooperation, we accept a small batch of 100g on the premise of full sample payment.
Q5: What is your delivery lead time?
A: Goods will be delivered within 3-5 working days after payment confirmation, excluding Chinese official holidays.
Q6: Is there a bulk purchase discount?
A: Yes, we adopt a tiered discount policy. Larger order quantity enjoys more favorable wholesale price.
