Propolis Extract

Propolis is a sticky solid gel formed by mixing plant resins collected by bees with their mandibular glands, wax glands and other secretions. Propolis is a mixture of plant compounds and bee secretions. Raw propolis is mainly composed of 50% resin, 5% pollen, 30% wax, 10% essential oil, and 5% various organic compounds (such as flavonoids, phenolic acids, esters , diterpenes, sesquiterpenes, lignans, aromatic aldehydes, alcohols) and amino acids, fatty acids, vitamins and minerals. Propolis has been used as a traditional folk medicine to treat a variety of diseases, and the polyphenols, flavonoids, and caffeic acid in propolis extract have been reported to improve metabolic syndrome. Propolis can also be used as an antibacterial agent to protect larvae and honey from external microorganisms.

COA

Item	Specification	Result	Test Method
Total flavonoids	≥20 %	22.40%	UV
Available Propolis content	≥96 %	98.00%	Ethanol distilling
Loss on Drying	≤5.0 %	1.6%	5g/105℃/3hr
Ash	≤5.0 %	0.4%	5g/800℃/3hr
Appearance	Black chunk with glossiness	conforms	Visual
Odor & Taste	With a Characteristic Bee Propolis Odor	conforms	Organoleptic
Total Heavy Metal	≤2 ppm	Conforms	Auto absorb method
Lead	≤1 ppm	0.89ppm	Auto absorb method
Chloramphenicol	≤0.3 PPB	Conforms	Elisa
Pesticide Residue	Negative	Negative	GC
Total Plate Count	≤1,000 cfu/g	Conforms	GB T 4789.2-2016
Total Yeast & Mold	≤50 cfu/g	Conforms	GB T 4789.15-2016
Escherichia Coli	Negative	Negative	GB T 4789.3-2016
Salmonella spp	Negative	Negative	GB T 4789.4-2016

Propolis Extract

1. Propolis extract has been found to improve diabetic complications by lowering glucose and blood lipid levels.
A research paper published in the journal Nature Communications titled: A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.
This research has made important progress in the research of CREB/CRTC2 protein-protein interaction inhibitors, a new target for diabetes. It was first verified that artepillin C, the main component of Brazilian propolis, can inhibit CREB/CRTC2 protein-protein interaction. It was verified that the natural product artepillin C blocks CREB/CRTC2 protein-protein interaction and regulates gluconeogenesis-related genes by binding to CREB. expression, thereby exerting the therapeutic effect of reducing fasting blood glucose.

2. Professor Gregory from Texas was the first to conduct modern clinical research on the effect of propolis on wound healing. He compared the effectiveness of propolis cream and silver sulfadiazine (SSD) in patients with minor second-degree burns. Propolis has been shown to be more effective than SSD at reducing inflammation and promoting healing. Some time later, scientists tested propolis, honey, and the healing of infected wounds in diabetic patients, demonstrating in a clinical study of a randomized controlled trial that over a four-week period of observation of the healing process of diabetic foot ulcers, 5 doses applied twice daily % propolis ointment has a beneficial effect on wound size. Furthermore, wound fluid from the group treated with propolis showed lower bacterial counts.

Reference

[1]. Oxidative Medicine and Cellular Longevity: "Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits."

[2]. Samadi N., Mozaffari-Khosravi H., Rahmanian M., Askarishahi M. Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: A randomized, double-blind clinical trial. J. Integr. Med. 2017;15:124–134. doi: 10.1016/S2095-4964(17)60315-7.

Propolis Extract