Synonyms: Vitamin B9, VB9, Acidum folicum,folate
CAS : 59-30-3
Formula: C19H19N7O6
Characteristics: Yellowish or orange, crystalline powder. no smell and no odor.
Assay:10%,80%,97.0%-102.0%
Grade:Food Grade and Pharmaceutical Grade
Category
Vitamins
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Description
Technical Parameters
1. Product Introduction
Folic Acid, also known as Vitamin B9 or Pteroylglutamic acid, is an essential water-soluble B-group vitamin widely used in food fortification, health supplements and pharmaceutical industries. It is necessary to distinguish synthetic folic acid from natural folate: synthetic folic acid is artificially synthesized with stable properties and high absorption rate; natural folate is extracted, reduced and methylated from fresh fruits and vegetables, and naturally exists in the human body in the form of L-5-methyltetrahydrofolic acid.
Folic acid cannot be independently synthesized by the human body and must be obtained through daily diet or exogenous supplementation. Green leafy vegetables, citrus juice and beans are the main natural food sources of folate. The daily demand for ordinary adults is 100~200μg/d, and the WHO recommended standard adult intake is 200μg/d. As a core nutritional vitamin, it participates in human genetic material synthesis, cell metabolism and multiple physiological regulation processes, with irreplaceable nutritional and medical value.
2. Complete COA Quality Test Report
Items
Specifications
Results
APPEARANCE
Orangish yellow powder
Visual
ODOUR
Characteristic
Olfactory
TASTE
Characteristic
Gustatory
IDENTIFICATION
Positive
Internal Method
ASSAY (on anhydrous basis)
95.0-102.0 %
Internal Method
WATER (Karl Fisher)
≤8.50 %
Internal Method
SULPHATED ASH
≤0.2 %
Internal Method
RESIDUE ON IGNITION
≤0.3 %
Internal Method
DENSITY
0.2-0.4 g/ml
Internal Method
RELATED SUBSTANCE
Complies
Internal Method
O.V.I.
Complies
Internal Method
PARTICLE SIZE
through 200µm
Internal Method
SOLUBILITY
Practically insoluble in water, ethanol, acetone, chloroform or ether. Soluble in alkaline hydroxide or diluted carbonate solution
ARSENIC
≤1.0 ppm
Internal Method
LEAD
≤3.0 ppm
Internal Method
CADMIUM
≤1.0 ppm
Internal Method
MERCURY
≤0.1 ppm
Internal Method
CHROME
≤2.0 ppm
Internal Method
TOTAL PLATE COUNT
≤100ufc/g
Internal Method
YEASTS AND MOULD
≤10ufc/g
Internal Method
E. COLI
Absence/g
Internal Method
SALMONELLA
Absence/10g
Internal Method
S. AUREUS
Absence/g
Internal Method
3. Core Physiological Functions & Efficacy
As an essential coenzyme for human metabolism, Folic Acid Vitamin B9 participates in nucleic acid synthesis, amino acid conversion, DNA/RNA replication and methylation regulation, and has multi-dimensional health regulatory functions:
1. Regulate Cell Metabolism & Genetic Synthesis
Folic acid acts as a key cofactor for biological reactions, involved in the biosynthesis of nucleic acids and amino acids. It regulates DNA and RNA replication and methylation processes, controls homocysteine levels in the body, and maintains normal cell growth and division, which is the basis for human tissue growth and repair.
2. Prenatal Nutrition & Fetal Development Support
It is an indispensable core nutrient for pregnant women and fetal development. Adequate folic acid supplementation effectively promotes fetal brain and neural tube development, reduces the risk of fetal developmental defects, and is a daily essential nutritional supplement for women of childbearing age and pregnant women.
3. Powerful Antioxidant Activity
Similar to Vitamin C and Vitamin E, folic acid has significant free radical scavenging ability. It eliminates oxidative free radicals in the body, reduces oxidative stress damage to cells, and delays body aging and tissue lesion degeneration.
4. Regulate Neurotransmitters & Improve Mental State
It participates in the synthesis of serotonin and dopamine in the human brain. These core neurotransmitters are closely related to emotional regulation. Reasonable folic acid supplementation helps relieve anxiety and depression and maintain stable mental and neurological health.
5. Protect Cardiovascular Health
Clinical studies have verified that standardized folic acid supplementation can reduce stroke risk by 10% and overall cardiovascular disease risk by 4%. It improves blood lipid metabolism and vascular microcirculation, effectively preventing various cardiovascular and cerebrovascular diseases.
6. Enhance Body Immunity
Folic acid deficiency will lead to decreased immune function. Targeted supplementation can repair and restore human immune cell activity, improve the body's disease resistance, and maintain immune system balance.
High Absorption Efficiency: Synthetic folic acid for oral and injection supplements has far higher bioavailability than natural food-source folate. Vitamin C can effectively inhibit folic acid degradation in gastric juice and further improve its absorption and utilization rate in the human body.
Widely Approved Food Fortification: In 1998, the U.S. FDA officially approved folic acid as a legal food fortifier, which is widely added in daily grain products such as bread, pasta and rice to realize public nutritional supplementation and prevent population folic acid deficiency.
5. Wide Application Fields
1. Food Fortification Industry
Used as a legal nutritional fortifier for grains, baked goods, beverages and daily processed foods to supplement human daily folic acid intake and solve universal nutritional deficiency problems.
2. Health Supplement Industry
Widely used in prenatal and postnatal care supplements, cardiovascular health products, immune regulation products and anti-aging nutritional tablets, covering daily health care of adults, pregnant women and the elderly.
3. Pharmaceutical Industry
Applied in the production of oral folic acid tablets and injectable folic acid preparations, used for clinical treatment and improvement of folic acid deficiency, anemia, cardiovascular sub-health and neurological metabolic disorders.
4. Biomedical Research
Used as a core experimental raw material for cognitive function research, cardiovascular disease prevention research and neurodevelopmental related medical studies.
6. Product Advantages
Stable High Purity: The product purity is stably controlled at 95.0%-102.0%, with strict impurity and heavy metal control, meeting food and pharmaceutical grade standards.
Ultra-Safe Indicators: All heavy metal and microbial indexes are far below international limit standards, safe for long-term food addition and human supplementation.
Good Processing Performance: Uniform powder fineness, stable density, reliable batch consistency, suitable for tablets, capsules, food fortification and various formula processing.
High Bioavailability: Synthetic folic acid has stable structure and high absorption rate, with better nutritional supplement effect than natural folate.
Reference
[1]. Castillo, Lancellotti C., Tur Mari, J. A., and Uauy, Dagach R. [Effect of folate and related nutrients on cognitive function in older people; systematic review]. Nutr.Hosp. 2012;27(1):90-102.
[2]. Hsu CY, Chiu SW, Hong KS, et al. Folic Acid in Stroke Prevention in Countries without Mandatory Folic Acid Food Fortification: A Meta-Analysis of Randomized Controlled Trials. J Stroke. 2018;20(1):99–109. doi:10.5853/jos.2017.01522.
7. Packaging & Storage
Packaging: Standard export packaging, support 1kg/bag, 25kg/drum and customized specifications.
Storage Conditions: Store in a cool, dry, dark and ventilated environment, sealed and moisture-proof, avoid high temperature and strong light to ensure stable product activity.
FAQ
Q1: What is the difference between synthetic folic acid and natural folate?
A: Synthetic folic acid has stable structure and higher human absorption rate, suitable for standardized nutritional supplementation and industrial production; natural folate is extracted from fruits and vegetables with mild properties, existing in the form of L-5-methyltetrahydrofolic acid in the human body.
Q2: What are the core effects of folic acid supplementation?
A: It mainly includes promoting fetal neural development, protecting cardiovascular health, scavenging free radicals and anti-aging, regulating mental emotions and enhancing body immunity.
Q3: Is your folic acid food and pharmaceutical grade compliant?
A: Yes. All indicators such as purity, heavy metals and microorganisms fully meet international food and pharmaceutical grade standards, supporting food fortification and pharmaceutical raw material applications.
Q4: Can you support customized processing and bulk supply?
A: We support long-term stable bulk supply and customized packaging, and can cooperate with OEM/ODM processing of folic acid finished supplements.