Leech Extract Hirudin

1. Product Introduction

Hirudin is a high-value active small-molecule polypeptide extracted from leeches and their salivary glands. Composed of 65–66 amino acids, it is recognized as the strongest natural specific thrombin inhibitor discovered to date. With unique molecular structure and biological activity, hirudin can specifically bind to thrombin and efficiently inhibit its activity. It features high safety, strong specificity and significant pharmacological effects, occupying an irreplaceable position in the research and clinical application of cardiovascular and cerebrovascular drugs. At present, hirudin is one of the most studied and most valuable active ingredients in leech extract.

2. Core Pharmacological Functions & Efficacy

2.1 Powerful Anticoagulant Effect

Hirudin exerts a unique targeted anticoagulant mechanism. It can specifically bind to both the catalytic site and fibrinogen binding site of thrombin, completely blocking thrombin activity. It effectively inhibits the conversion of fibrinogen into fibrin and prevents cross-linking of fibrin monomers, thereby fundamentally blocking pathological blood clot formation. Different from traditional anticoagulant raw materials, it will not cause excessive bleeding risk and features mild action and high safety.

2.2 Significant Thrombolytic & Recanalization Effect

Apart from inhibiting new thrombus generation, hirudin can significantly activate endogenous plasmin activity, accelerate the degradation and dissolution of mature thrombus, and recanalize occluded blood vessels. It achieves dual effects of anticoagulation and thrombolysis, effectively improving blood microcirculation. It has important clinical significance for the prevention, treatment and postoperative rehabilitation of ischemic cardiovascular and cerebrovascular diseases such as cerebral stroke, myocardial infarction and peripheral venous thrombosis.

2.3 Anti-inflammatory & Antioxidant Activity

Hirudin delivers excellent anti-inflammatory and antioxidant dual effects. It effectively inhibits the activation, migration and chemotaxis of inflammatory cells, reduces the release of TNF-α, IL-6 and other pro-inflammatory mediators, and relieves vascular and tissue inflammatory lesions. Meanwhile, it scavenges excess intracellular free radicals, reduces oxidative stress damage to vascular endothelial cells, improves tissue antioxidant capacity, and alleviates inflammatory injury caused by ischemia-reperfusion.

2.4 Vascular Endothelial Protection & Anti-thrombosis

It can effectively inhibit abnormal platelet aggregation induced by multiple pathways, protect the integrity and physiological function of vascular endothelial cells, repair damaged vascular intima, and improve systemic microcirculation. It can prevent vascular intimal hyperplasia and recurrent thrombosis, maintain vascular patency, and provide long-term protection for cardiovascular and cerebrovascular systems.

2.5 Organ Protective Effect

By improving local blood perfusion, inhibiting inflammatory infiltration and reducing oxidative damage, hirudin relieves ischemic and hypoxic injury of heart, liver, kidney and other vital organs. It effectively protects organ physiological functions, reduces organ tissue edema and necrosis caused by thrombosis and inflammation, and assists in improving the prognosis of cardiovascular and visceral lesion diseases.

2.6 Anti-tumor Potential

Modern pharmacological studies have confirmed that hirudin has definite anti-tumor auxiliary activity. It can inhibit tumor angiogenesis to cut off tumor nutrient supply, block platelet-tumor cell adhesion and metastasis, and regulate tumor microenvironment. It restrains tumor proliferation, invasion and distant metastasis, providing a new research direction for clinical anti-tumor adjuvant therapy.

2.7 Antibacterial Activity

Hirudin has broad-spectrum antibacterial and anti-adhesion properties. It interferes with bacterial metabolic activity and thrombin-like enzyme production, inhibits bacterial growth, colonization and adhesion on tissue surfaces, reduces the risk of bacterial infection and biofilm formation, and assists in improving local inflammatory and infectious symptoms.

3. Main Application Fields

3.1 Prevention & Treatment of Thrombotic Diseases

As a high-efficiency, safe and low-side-effect natural anticoagulant raw material, pharmaceutical-grade hirudin is widely used in the research, development and production of drugs for various thrombotic diseases. It is applicable for prevention and clinical treatment of myocardial infarction, ischemic stroke, cerebral infarction, deep vein thrombosis and pulmonary embolism, realizing dual prevention and treatment of thrombosis-related diseases.

3.2 Minimally Invasive & Replantation Surgery

It is an essential anticoagulant raw material for vascular interventional minimally invasive surgery, including coronary angioplasty and vascular stent implantation, effectively preventing intraoperative and postoperative vascular thrombosis. In limb and tissue replantation surgery, it maintains anastomotic vascular patency, reduces ischemic necrosis and postoperative thrombosis risk, and significantly improves surgical survival rate.

3.3 Hemodialysis Treatment

For patients undergoing long-term hemodialysis and peritoneal dialysis, traditional anticoagulants are prone to drug resistance and side effects. Hirudin, with high safety and targeted anticoagulation, can effectively prevent blood coagulation in dialyzers and pipeline systems, ensure stable and smooth dialysis treatment, and reduce dialysis complications and secondary damage.

3.4 Biomedical Research & Clinical Trials

With stable chemical properties and pure activity, hirudin is widely used in biomedical basic research, pharmacological experiments and clinical trial sample processing. It serves as a high-standard natural anticoagulant reagent to maintain the original physiological state of blood samples, effectively avoiding sample coagulation and component changes, and ensuring experimental and detection accuracy.

4. Factory Strength & Quality Control System

We own standardized plant extraction workshops and Class D aseptic purification workshops, with complete industrial production and purification equipment: 6 sets of 6m³ multi-functional extraction units, 4 sets of 5m³ reaction kettles, 7 sets of 1500kg/h external circulation evaporation and concentration systems, 4 sets of 2m³ high-precision chromatographic purification columns, 1 set of 250kg/h low-temperature spray drying tower, and 1 set of 2000kg/h alcohol rectifying and recovery tower. All production links meet pharmaceutical-grade production standards.

We have a professional technical R&D team and skilled production staff. Strict raw material selection and incoming inspection standards are implemented throughout the production process. A full-link quality control system covers raw material procurement, extraction, purification, drying, testing and finished product delivery. Every batch of products undergoes strict HPLC purity detection, heavy metal analysis and microbial testing to ensure stable 99% high purity, low impurities and excellent batch consistency.

Our company actively expands domestic and international market layout and industry exchanges. We have participated in many professional domestic plant extract and biopharmaceutical exhibitions, and attended the Western US Professional Exhibition in October 2023. We sincerely welcome global customers to consult, negotiate cooperation and visit our factory.

1. Treatment of blood coagulation diseases: it is a powerful anticoagulant, which can be used to prevent and treat diseases related to thrombosis, such as myocardial infarction, stroke, deep vein thrombosis, etc. It can inhibit the activity of thrombin, block the formation of thrombus, and promote the dissolution of thrombus.

2. Minimally invasive surgery and replantation surgery: It can be used for some minimally invasive surgery that requires anticoagulant treatment, such as angioplasty, vascular stent implantation, etc. In addition, in tissue replantation surgery, it can help promote the patency of reconnected blood vessels, reducing ischemic damage and thrombosis.

3. Hemodialysis: It is also used in hemodialysis. For those patients who need long-term hemodialysis treatment, in order to avoid blood coagulation in the dialyzer, it can be added to the blood to play an anticoagulant effect.

4. Clinical trials and research: It is also used in some clinical trials and research. It can be used as an anticoagulant in the processing of blood samples to keep the original state of the blood samples.

Double polyethylene bags inside, and high-quality standard carton drum outside.

Shipping by express, air, Sea, and some special line to most Countries

We have our own plant extraction workshop and OEM aseptic workshop.

The company has strong technical force and experienced production staff. The company has 6 sets of 6m3 modern multi-functional extraction equipment, 4 sets of 5m3 reactors, 7 sets of external circulation evaporation and concentration equipment with an evaporation capacity of 1500kg/h, 4 sets of chromatographic columns with a volume of 2m3, and an evaporation capacity of 250kg/h spray One set of drying tower, one set of rectifying alcohol 2000kg/h rectifying tower, 400㎡ of Class D clean area.

    The company not only has advanced technology and professional equipment, but also has a sound system and strict and professional standards in raw material selection and procurement, ensuring a complete and comprehensive quality control system from raw material procurement to product delivery.

We have participated in the domestic professional exhibition of plant extracts, and we are going to participate in the western United States exhibition in October 2023. Welcome to visit us.

FAQ

Q1: Can I get free Hirudin powder samples?

A: Yes, we provide free product samples. Customers only need to bear the shipping cost.

Q2: What is the advantage of natural hirudin compared with synthetic anticoagulants?

A: Natural hirudin features strong specificity, high safety, significant efficacy and low side effects, with dual anticoagulant and thrombolytic functions, which is superior to single-effect synthetic anticoagulant ingredients.

Q3: What is your product purity and batch stability?

A: Our hirudin purity reaches 99%, with ultra-low impurities, compliant with pharmaceutical-grade standards, and stable batch quality.

Q4: What is your MOQ and delivery time?

A: Standard MOQ is 1kg. In-stock products can be delivered within 3–5 working days after payment confirmation.

Q5: Do you support customized specifications and OEM services?

A: Yes, we support customized product specifications and related OEM processing services to meet diverse customer application needs.