Echinacoside (ECH) is a phenylethanoid glycoside compound extracted from traditional Chinese medicine. It is mainly derived from Cistanches tubulosa and was first found in the rhizomes of Echinacea.
Currently, echinacoside can be extracted from traditional Chinese medicines such as Cistanches Herba, Scrophulariae Radix, and Rehmanniae Radix. The 2020 edition of the Chinese Pharmacopoeia also uses it as a quality control indicator for Cistanches Herba. In Cistanches tubulosa, the content of echinacoside is as high as 30%, which is the main active ingredient of Cistanches Herba.

Echinacoside

Analysis Item	Specification	Result	Test Method
Active Ingredeints：Echinacoside>10%-40%, Acteoside>4%-16%
Extract Ratio	10:1	Complies	TLC
Appearance	Yellow powder	Complies	Visual
Odor	Characteristic	Complies	Olfactory
Sieve Analysis	100% pass 80 mesh	Complies	80 mesh Screen
Loss on Drying	≤ 5%	2.17%	USP32<561>
Ash	≤ 5%	1.49%	USP32<731>
Arsenic (As)	≤ 1 ppm	0.11 ppm	USP32<231>
Cadmium(Cd)	≤ 0.5 ppm	0.15 ppm	USP32<231>
Lead (Pb)	≤ 0.5 ppm	0.04 ppm	USP32<231>
Mercury (Hg)	≤ 0.1 ppm	0.02 ppm	USP32<231>
Residual solvents	Meet USP32 Requirments	Conforms	USP32<467>
Heavy Metals	≤ 10 ppm	Complies	USP32<231>
Residual pesticides	Meet USP32 Requirments	Conforms	USP32<561>
Total Plate Count	≤ 1000 cfu/g	Complies	USP34<61>
Yeast & Mold	≤ 100 cfu/g	Complies	USP34<61>
E.Coli	Negative	Complies	USP34<62>
Staphylococcus	Negative	Conforms	USP34<62>
Staphylococcus aureus	Negative	Complies	USP34<62>
Conclusion:	Meet the standard

What is the function of Echinacoside?

Studies have shown that cistanche deserticola extract echinacoside has a wide range of pharmacological activities, including neuroprotection, anti-inflammatory, antioxidant, antiviral, and cardioprotective activities.
A large number of basic studies have confirmed that echinacoside has therapeutic effects in neurological diseases such as Parkinson's disease, Alzheimer's disease, and cognitive impairment.

Echinacoside improves neuroinflammation through different anti-inflammatory pathways, protects dopaminergic neurons, reduces neuronal damage, and inhibits the deposition of α-synuclein, thereby improving Parkinson's disease.
In vivo and in vitro research data published at home and abroad show that ECH has a neuroprotective effect in the prevention and treatment of neurodegenerative diseases. A large number of studies have shown that ECH has a variety of effects on improving neuronal function, including anti-inflammatory, anti-oxidative stress, protection of mitochondrial function, and regulation of autophagy. And echinacoside can cross the blood-brain barrier, indicating that it has potential in the treatment of neurological diseases.

The anti-aging effect of echinacoside. This substance can increase INF-γ in serum, reduce the content of IL-6, and delay the occurrence of aging by regulating cellular immunity. In addition, echinacoside can delay cell aging by inhibiting the expression of TGF-β1 and p53 genes in the kidneys.

Echinacoside