In clinical, scopolamine is available in two forms: scopolamine hydrobromide and scopolamine butylbromide. Scopolamine hydrobromide is the hydrobromide of scopolamine extracted from Solanaceae plants such as Atropa belladonna, Datura stramonium, and Scopolamine. Butylscopolamine butylbromide is a drug obtained by quaternization of scopolamine, which has a butylbromide group in its structure, rather than the butylbromide of scopolamine.
Scopolamine was first developed by E. Schmidt in 1892 when it was isolated from scopolamine.
Anisodamine is mainly an alkaloid extracted from the root of Solanaceae plant Anisodamine. The natural product is anisodamine hydrobromide, and the synthetic product is called racemic anisodamine. Both are M cholinergic receptor blockers.

Scopolamine hydrobromide powder

Analysis	Specification	Result	Test method
Assay-Colourimetric	98.5 - 102% max	99.16%	USP24
Appearance	White crystalline powder or colourless crystals, freely soluble in water, soluble in ethanol (96%) and practically insoluble in ether.	Complies	Visual
Identification	B. Comparative infrared spectra with CRS Hyoscine Hydrobromide	Must comply	EP4 method 2.2.24
	D. Reaction of residue after Nitric Acid as per monograph	Must comply	EP4 identification test C
Melting point (dried)	Report	196.7℃	EP4 method 2.2.14 (mod)
pH -5% solution	4.0 – 5.5	4.53	EP4 method 2.2.3
Specific optical rotation on a solution (S) as per monograph	Negative 24°to negative 27°	Negative 26°	EP4 method 2.2.7
Apoatropine permanganate color	Color retained after 5 min.	Complies	USP24 purity method (3)
Loss on drying (on 5g)	13.0% max	12.0%	EP4 method 2.2.32 (mod)
Residue on Ignition (1g)	0.1% max	0.11%	EP4 method 2.4.14
Residual solvents	60 mg/kg max	Complies	EP 6 edition method 2.4.24
Conclusion	Complies with the standards.
General Status	Non-GMO, ISO Certificated.

Scopolamine hydrobromide powder

1. Scopolamine hydrobromide has a strong effect on pupil and glandular secretion.
2. Scopolamine hydrobromide not only has peripheral anticholinergic effects, but also central anticholinergic effects. It easily passes through the blood-brain barrier. Its effect on the central nervous system is mainly inhibitory. It has a sedative and hypnotic effect on the brain and an excitatory effect on the respiratory center.
3. It has a central anticholinergic effect, which determines that it can also be used to treat motion sickness such as seasickness and motion sickness.

What is scopolamine hydrobromide used for?

The clinical application dosage forms of scopolamine hydrobromide powder raw materials include tablets, injections, patches, etc. Among them, patches are often used to relieve seasickness, motion sickness, etc.

Scopolamine hydrobromide powder