PRODUCT OVERVIEW & BIOAVAILABILITY ENHANCEMENT
Turmeric (Curcuma longa L.) is an ancient botanical renowned for centuries in Ayurvedic and traditional medicine. In 2018, Turmeric ranked fifth among the most popular dietary supplements among U.S. consumers, establishing itself as a foundational pillar in global joint health and systemic anti-inflammatory supplementation.
The Challenge: Raw turmeric root contains only 1% to 6% native curcuminoids. Furthermore, native curcumin is highly hydrophobic, poorly absorbed in the human gastrointestinal tract, rapidly metabolized via hepatic glucuronidation, and rapidly cleared from systemic circulation, resulting in extremely low native bioavailability.
The Prius Biotech Bioavailability Solution:
95% Active Standardization: Our extraction isolates and purifies the full three-curcuminoid complex (Curcumin, DMC, and BDMC) to >= 95.0% purity, ensuring consistent physiological potency.
Piperine Synergy (BioPerine Co-Administration): Black pepper extract standardized to 95% Piperine inhibits hepatic and intestinal aryl hydrocarbon hydroxylase and UDP-glucuronosyltransferase. Co-administering just 20 mg of piperine with curcumin increases serum curcumin concentrations and bioavailability by up to 2,000% (20 times) in human clinical trials without adverse effects.
According to measurements, the curcumin content in turmeric is between 1% and 6%. If you want a higher absorption rate, curcumin capsules would be a better choice.
Our curcumin capsule is made from organic turmeric root and organic turmeric extract, standardized to provide 95% curcumin.
In 2018, Turmeric Supplement ranked fifth among the most popular dietary supplements among U.S. consumers.
Our curcumin supplement is manufactured under strict cGMP and our turmeric and black pepper raw material is third-party tested.
1. Black pepper extract + curcumin
Our innovative formula includes black pepper extract alkaloids.
Curcumin is not easily absorbed, and turmeric supplements often contain piperine, which can greatly increase the bioavailability of curcumin. For example, it has been reported that taking 20 mg of piperine with turmeric can increase its bioavailability in serum by 20 times.
Curcumin capsules show certain therapeutic effects in chronic inflammation, elevated transaminase, muscle fatigue, heart failure, knee arthritis and vascular endothelial function.
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SCIENTIFIC HEALTH BENEFITS & PHARMACOLOGICAL MECHANISMS
Osteoarthritis Relief & Joint Mobility: Curcumin blocks the phosphorylation and nuclear translocation of Nuclear Factor-kappa B (NF-kB), downregulating cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6). In patients with knee osteoarthritis, clinical dosages ranging from 40 mg to 2,000 mg daily for 4 to 36 weeks significantly reduce joint stiffness, improve Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, and relieve pain comparably to standard NSAIDs, with superior gastric safety.
NAFLD Support & Transaminase Normalization: In patients with Non-Alcoholic Fatty Liver Disease (NAFLD), curcumin supplementation downregulates sterol regulatory element-binding protein 1c (SREBP-1c) and upregulates PPAR-alpha. This significantly lowers elevated serum liver transaminases (Alanine Aminotransferase [ALT] and Aspartate Aminotransferase [AST]), improves hepatic ultrasound steatosis scores, and reduces circulating total cholesterol and triglycerides.
Endothelial Protection & Cardiovascular Vigor: Curcumin upregulates endothelial nitric oxide synthase (eNOS) activity, promoting nitric oxide (NO) generation and vascular smooth muscle relaxation. It suppresses oxidative vascular remodeling, improves flow-mediated dilation (FMD), and supports ventricular performance in early-stage heart failure models.
Muscle Fatigue & Exercise Recovery: Curcumin suppresses exercise-induced systemic muscle damage markers (creatine kinase and lactate dehydrogenase), scavenging exercise-induced reactive oxygen species (ROS) and alleviating Delayed Onset Muscle Soreness (DOMS).
TARGETED FORMULATION PLATFORMS (CUSTOM OEM/ODM BLENDS)
Platform A: High-Bioavailability Joint & Comfort Complex (Market Standard) Standardized Curcuminoids 95% (500mg) + BioPerine Black Pepper Extract 95% (5mg). Application: Two-piece vegetarian capsules or film-coated tablets for daily joint comfort and systemic inflammation defense.
Platform B: Triple-Action Osteo-Mobility Matrix Curcuminoids 95% (400mg) + Boswellia Serrata Extract (65% Boswellic Acids / 20% AKBA, 150mg) + Ginger Root Extract (5% Gingerols, 100mg) + BioPerine (5mg). Application: High-potency mobility caplets for advanced joint flexibility.
Platform C: Liver Metabolic Detox & NAFLD Support Curcuminoids 95% (300mg) + Milk Thistle Extract (80% Silymarin, 250mg) + Artichoke Leaf Extract (5% Cynarin, 100mg) + Dandelion Root Extract + BioPerine (5mg). Application: Liver care capsules for transaminase and blood lipid regulation.
Platform D: Anti-Inflammatory Cardio & Cellular Defense Softgel Lipid-based Curcumin Extract + Cold-Pressed Flaxseed Oil (ALA Omega-3) + Natural Vitamin E + Coenzyme Q10. Application: Liquid-filled softgel capsules delivering lipid-micellar enhanced absorption.
What are turmeric supplements good for?
1. Supports joint health: Turmeric is a common ingredient found in joint support supplements because its phytonutrients can enhance joint comfort and mobility.
40mg-2000mg of turmeric extract or curcumin daily for 4-36 weeks generally improved inflammation severity and pain levels in these arthritis patients with a good safety profile.
2. Supplementation of curcumin has a favorable effect on serum liver enzymes and serum total cholesterol in patients with non-alcoholic fatty liver disease. Curcumin is considered to be an auxiliary therapeutic substance for patients with non-alcoholic fatty liver disease.
3. Curcumin is a natural anti-inflammatory drug with relatively few toxic side effects. Studies have shown that it has certain effects on acute, subacute and chronic inflammation.
Reference
[1]. Zeng L, Yu G, Hao W, Yang K, Chen H. The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis. Biosci Rep. 2021 Jun 25;41(6):BSR20210817.
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