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Dihydroartemisinin (also known as dihydroqinghaosu, artenimol or DHA) is a drug used to treat malaria.
Recent multi-centre trials showed that dihydroartemisinin-piperaquine (DP) was as efficacious and safe as artemether-lumefantrine (AL) for treatment of young children with uncomplicated P. falciparum malaria across diverse transmission settings in Africa. Longitudinal follow-up of patients in these trials supported previous findings that DP had a longer post-treatment prophylactic effect than AL, reducing the risk of reinfection and conferring additional health benefits to patients, particularly in areas with moderate to high malaria transmission.
1.Artesunate is an antimalarial agent. It is a water-soluble hemisuccinate derivative of dihydroartemisinin.
2.Artemisinin is a sesquiterpene lactone isolated from Artemisia annua, a herb that has traditionally been used in China for the treatment of malaria.
3.Artesunate and its active metabolite dihydroartemisinin are potent blood schizonticides, active against the ring stage of the parasite.
4.Artesunate is ideal for the treatment of severe malaria, including cerebral malaria. It is also active against chloroquine and mefloquine resistant strains of P. falciparum.
5.Artesunate is unstable in neutral solution and is therefore only available for injections as artesunic acid
1. With function of controlling of vivax malaria and falciparum malaria symptom, as
well as treatment of chloroquine-resistant strain of insect.
2. With function of oxidant. artemisinin is reduced by catalase,dithiothreitol and
3. With the function of antibacterial, artemisinin has anti-influenza virus effect.
4. With the function of anti-parasite, artemisinin on the role of anti-schistosomiasis and leptospirosis.
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