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Naringin is the major flavonoid glycoside in grapefruit and gives grapefruit juice its bitter taste. It is metabolized to the flavanone naringenin in humans. Both naringin and hesperetin, which are the aglycones of naringin and hesperidin, occur naturally in citrus fruits. Naringin exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of selected drug metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug drug interactions in vivo. Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels.
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◆ Pomelo (Grapefruit) contains a lot of vitamin C, can reduce blood cholesterol.
◆ Narigin is related to other flavanones known to have therapeutic action in influencing capillary permeability.For those pharmcetical uses the better solubility of naringin in water is an advantage.
◆ Narigin is citrus flavanoid commonly found in grapefruit,and is responsible for grapefruit's distinctive biter taste. Most of us have heard how it's important to be careful consuming grapefruit juice along with certain medications, studies reveal that naringin interferes with some digestive enzymes which can affect the metabolism and breakdown of these drugs, this can effect lead to an inadvertantly higher dose of the drug, which may pose the threat of adverse reactions and naringenin price that everyone can accept.
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