Citrus aurantium extract hesperetin 98% is the derivative of hesperidin after treated with acid hydrolysis or enzyme catalysis.
Hydrolysis by hesperidin
Used Herbal Part
Slightly soluble in water; Easily soluble in ethanol.
Citrus aurantium extract hesperetin 98% is the derivative of hesperidin after treated with acid hydrolysis or enzyme catalysis. Commercial can be obtained by hydrolyzation and enzyme catalysis from Hesperidin (extracted from immature citrus fruit). It is in the solid form and with poorly soluble in water. It is one of the bioflavonoid in citrus bioflavonoid with multiple function like antioxidant, reducing cholesteryl ester mass , antiflammatory, anti-allergic and so on. And only few can found naturally in citrus family plant.
It is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. It may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic,vasoprotective and anticarcinogenic actions.
Mechanism of Action
Citrus aurantium extract hesperetin 98% reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. It also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels.
Citrus aurantium extract hesperetin has properties of antioxidant,anti-inflammatory, anti-allergic, hypolipidemic,and anticarcinogenic actions. It can also act as a vasodilator, which may be useful in Hypertension.
It is also used in functional food or dietary supplement as its properties. More studyings are in process to enlarge its use in more industries.
Commercial citrus aurantium hesperetin can be obtained by hydrolyzation from Hesperidin (extracted from immature citrus fruit).
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