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Stevia Extract Has Anti-tumor Effect

Sep 16, 2017

As we all know, Stevia extract’s main ingredient is Stevioside.

Studies have shown that Stevia extract does not affect blood glucose levels or interfere with insulin. Stevia extract does not contain any calories and can give diabetics more flexibility in estimating total calorie intake and helps to control weight. No matter how the ingestion of stevia extract, the glycemic index GI has no effect. Stevia extract can also be used for a variety of food and beverage, single use and use level may vary depending on the country. Stevia extract and other sweeteners used in combination, there will be synergistic effect.

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Recently, the researchers found more nutrients in addition to stevioside , including non-glycoside diterpenes, chlorogenic acid, flavonoids and vitamins.


However, the latest study also shows that stevioside extract has stronger effect on tumor cells antioxidant and anti-proliferative than diterpene glucoside。


In order to assess the toxicity of stevia, the researchers conducted a large number of experiments in vitro and in vivo. The study recorded a negative effect of bacterial reverse mutation analysis, mouse bone marrow micronucleus test and mouse sperm abnormality analysis. Studies showed that the oral drink concentration of 1.04%, 2.08% and 3.12% of the stevia extract did not cause behavioral, hematological, clinical or histopathological changes in rats over a 90-day period. In addition, no significant differences in food intake and body weight were observed between the test and control groups in the 90-day study without death or treatment-related adverse outcomes.

Researchers tested long-term oral stevia extract from female rats in the highest dose group and showed a significant reduction in cholesterol, protein and albumin levels in rats.

Studies on the toxicity of stevia extract showed that both genotoxic and chronic oral toxicity did not reach 300 times the recommended daily intake. Scientific research data demonstrate the safety of the stevioside bioactive ingredient, so it can act as a functional active ingredient in functional foods and nutritional supplements.

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