Xi'an Prius Biological Engineering Co.,Ltd
Address:Room 0836,Euro-Asia International Building A,Ouya avenue ,Xi'an,Shaanxi Province ,China.
Gastric cancer is a malignant tumor derived from gastric mucosal epithelium. According to the 2018 International Agency for Research on Cancer (IARC), gastric cancer is still one of the most malignant tumors with the highest morbidity and mortality in the world. Because of its rapid onset and difficulty in early diagnosis, most patients have entered the middle and late stages when they are diagnosed, which brings great difficulties to clinical treatment.
Turmeric Extract Powder is a low-molecular-weight polyphenolic compound extracted from the rhizome of traditional Chinese medicine turmeric. Studies have shown that curcumin has a wide range of biological activities, including hypolipidemic, antiepileptic, and antidepressant effects.
Although cytotoxic drugs play an important role in gastric cancer chemotherapy, due to their large toxic and side effects, causing great pain and adverse reactions to the treatment of patients, coupled with repeated chemotherapy is easy to cause cancer cell acquired resistance, to a certain extent limited The clinical use of such drugs.
In recent years, the anti-tumor effect of Turmeric extract powder has attracted extensive attention from scholars at home and abroad, and its mechanism may be related to the induction of tumor cell apoptosis, affecting the tumor microenvironment and inhibiting tumor signal transduction. Curcumin can also reverse tumor cell resistance through various mechanisms, including reversing oxaliplatin resistance in rectal cancer by regulating CXC chemokine / NF-κB signaling; targeting Wnt2 / β-catenin pathway to reverse multidrug resistance in esophageal cancer Drugs; and inhibit the NF-κB signaling pathway to reverse the resistance of gastric cancer cell Herceptin.
Previous studies have shown that the Wnt3a / β-catenin / EMT pathway is abnormal in MKN45 and NCI N87 cells, suggesting that this pathway may be a potential target for gastric cancer treatment, and whether curcumin can act on this pathway to inhibit the proliferation of gastric cancer cells and thereby induce their apoptosis Death, need to be explored.If you want know more, please contact: [email protected]