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What are the effects of the main monomer saponins of Panax notoginseng?

Nov 10, 2020

Saponins are the foundation of the health-preserving and curing effects of Panax notoginseng and the main active ingredient. So far, more than 70 monomeric saponins have been isolated from different parts of it, some of which are unique to Panax notoginseng, and the most are Rg1, Rb1, R1, and Rd. The content of notoginseng saponins is one of the main criteria for evaluating the intrinsic quality of notoginseng.

The efficacy of the main monomer saponins of Panax notoginseng:

main monomer saponins of Panax notoginseng

Ginsenoside Rb2

Inhibit central nervous system, promote DNA and RNA synthesis, anti-hemolysis, anti-diabetic;

Ginsenoside Rd

Enhance immune function and inhibit the growth of cancer cells;

Ginsenoside Rh2

Promote the transformation of cancer cells into non-cancer cells;

Ginsenoside Rg1

Stimulate the central nervous system, enhance memory, resist fatigue, promote DNA and RNA synthesis, and resist platelet aggregation;

Ginsenoside Rg2

Anti-platelet aggregation;

Ginsenoside Rh1

Promote the transformation of cancer cells into non-cancer cells;

Ginsenoside Rb2

Induce the differentiation of leukemia cells.

Pharmacological effects of panax notoginseng saponins:

Pharmacological effects of panax notoginseng saponins

Effect on hyperlipidemia

It has obvious anti-platelet aggregation and defibrinating effects, and it has obvious preventive and therapeutic effects on hyperlipidemia.

Effect on hyperviscosity

It can significantly reduce the surface activity of platelets, inhibit platelet adhesion and aggregation, resist thrombosis, and improve microcirculation.

Effect on hypertension

Using panax notoginseng saponins to treat hypertension, after 20 days of treatment, can significantly reduce blood pressure, significantly slow down heart rate, increase red blood cell deformability, and reduce red blood cell aggregation.

Anti-myocardial ischemia effect

It can significantly improve the performance of ischemia and reduce the scope of myocardial infarction. It can reverse the left ventricular diastolic dysfunction of patients with fatigue-type angina and even restore it to normal.

Anti-arrhythmia

It can significantly shorten the duration of arrhythmia and reduce the incidence of acute myocardial infarction and arrhythmia.

Anti-atherosclerosis effect

It has a protective effect on vascular smooth muscle cells, can protect cells from high-fat serum, and has a certain preventive effect on atherosclerosis.

Anti-thrombosis, improve microcirculation

It can significantly reduce the surface activity of platelets, inhibit platelet aggregation and adhesion, resist thrombosis, and improve microcirculation.

Anti-cardiocerebral ischemia effect

It has a good clinical treatment effect on the acute phase of cerebral infarction, and it can significantly improve cerebral edema during global cerebral ischemia or focal ischemia-reperfusion.

Promote the growth of hematopoietic cells

Studies have found that Rg1 and Rb1 in Panax notoginseng saponins are effective monomers for promoting hematopoiesis, which can continuously promote the proliferation of human bone marrow granule and erythroid hematopoietic progenitor cells.

Protective effect on nerve cell damage

Panax notoginseng saponins have a protective effect on nerve cell damage caused by energy metabolism disorders.


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