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What Are the Basic Cardiovascular Pharmacological Effects of Celery Extract Powder and its Clinical Application?

Mar 16, 2020

Celery contains a variety of pharmacologically active ingredients. Such as flavonoids, volatile oil compounds and so on. Drugs are extracted from celery extract powder or its monomer extract can produce a variety of medicinal effects in clinical application. Such as reducing blood lipids, ischemic cardiovascular and cerebrovascular diseases. The following summarizes the basic cardiovascular pharmacological effects of celery and its clinical application.


Disorders of lipid metabolism and elevated blood lipid levels in the body can significantly accelerate the formation of atherosclerosis, thereby increasing the incidence of cardiovascular disease. In recent years, researchers have focused on certain natural plant components with a cholesterol-lowering effect. Because celery is rich in flavonoids, it has functions of lowering blood pressure, soothing nerves, lowering blood lipids, protecting blood vessels and enhancing immunity.


celery extract powder

Protective effect of myocardial ischemia-reperfusion injury

Researchers applied a rabbit model of isolated myocardial ischemia and reperfusion, and added celery extract 100 mg • kg -1 to Thomas solution. The results showed that celery extract can effectively increase coronary flow (P <0. 05), can significantly reduce the content of MDA (P <0.05), and reduce the activity of SOD and Lim (p <0.05).

 

Antihypertensive effect

The main active ingredients of celery extract powder are to lower blood pressure and lipid, and its main active ingredients are derivatives of coumarin and furanocoumarin. In addition, celery A, hirudin, 7-methyl hirudin Flavonoids such as melanin may also be effective ingredients in the treatment of hypertension.


Lipid-lowering effect

Dietary fiber in celery plays an important role in the lipid-lowering process. Cholesterol in the liver is metabolized to bile acid, which reaches the small intestine to digest fat, and then bile acid is absorbed by the small intestine back to the liver and converted to cholesterol. Dietary fiber absorbs bile acid in the small intestine, so that bile acid cannot be absorbed back to the liver by the small intestine. But it is excreted through the digestive tract along with the fiber. In order to digest the fat that constantly enters the small intestine, the liver can only supplement the lost bile acid by absorbing the cholesterol in the blood, which reduces the cholesterol in the blood. The flavonoid extract of celery has a regulating effect on blood lipids. After quantitatively administering celery extract to the stomach regularly, the serum TC, TG and HDL2C contents were measured regularly. So it has proved that celery extract has the functions of significant antihypertensive and hypolipidemic.

 

The pharmacological action of celery is the result of the action of various ingredients. For example, flavonoids, butyl phthalide, amino acids, unsaturated fatty acids and other active substances in celery extract powder have physiological functions of lowering blood pressure and lipid, so celery extract has the antihypertensive and hypolipidemic effect.

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