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The researchers found human targets for ginseng saponins

Dec 10, 2020

The reporter learned that Professor Jin Yinghua’s research group from the Key Laboratory of Molecular Enzyme Engineering of the Ministry of Education used phage display technology to systematically screen the cDNA library of human hepatocarcinoma cells from Jilin University, they obtained 47 targets of ginsenoside Rh2, which will provide new ideas for research on ginseng anti-cancer .

ginsenoside Rh2

ginsenoside

Professor Jin Yinghua said that research aims to prove the efficacy of ginseng by modern biological . The research results clarified the molecular mechanism of ginsenoside Rh2 (20S-G-Rh2) through targeted binding and other methods to inhibit tumor growth and relieve tumor drug resistance. The research results have been recently published in "Science Reports", a subsidiary of "Nature". The discovery of the human molecular target of ginsenosides scientifically explained the molecular mechanism of ginseng preventing and interfering with the occurrence and development of cancer, the pharmacodynamics and mechanism of action of traditional Chinese medicine were explained through modern biological methods, which provided new ideas, thoughts and research directions for the study of functions.

tumor cells and ginseng pharmacological

Lee Seung-ki, a professor at the School of Pharmacy of Seoul National University in South Korea who has long been engaged in the research of tumor cells and ginseng pharmacological , he said that the efficacy and role of ginsenosides have been highly concerned by the international academic community. The results of the research are the understanding of the anti-cancer efficacy of ginseng at the molecular level. which provide important clues to help the development of anti-cancer drugs and the industrialization of ginseng in the future.

Ginseng is a precious plant, known as "the king of herbs and the first of herbs", ginsenoside Rh2 is the main active substance of ginseng. It was isolated for the first time in 1963, but its human cell target has not been confirmed, making it difficult to clarify the molecular mechanism of ginseng's efficacy. it is not fully recognized and used in modern Western medicine.


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