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Tinospora cordifolia is a plant of the genus Cymbidium of Tetrandraceae, which is a traditional anti-diabetic drug in India. It contains many chemical constituents. Alkaloids and diterpenoids have been isolated. It is widely used in India to treat diabetes, jaundice, rheumatoid arthritis, gout, fatigue, skin diseases, infectious diseases and other diseases. It is also a commonly used anti-diabetic drug in India. Pharmacological studies have shown that it has hepatoprotective effect, immune stimulation and hypolipidemic effect. Let's take a look at its pharmacological effects.
1.1 Hypoglycemic and hypolipidemic effects
Studies have shown that Tinospora cordifolia extract has the effect of lowering blood sugar in experimental diabetic rats. JK Grover and other studies has evaluated the anti-hyperglycemic effects of water extract, ethanol extract and low-pressure freeze-dried extract of heart-leaf green cattle bile on diabetic rats. From what has above studies showed that Tinospora cordifolia has a strong effect on reducing blood sugar and blood lipid in diabetic rats, and the hypoglycemic activity of saponin, a glycosidase inhibitor, is better than that of acarbose.
1.2 Antioxidant Stress
P. Stanely Mainzen Prince and other studies have studied the preventive effect of water extract on Tinospora cordifolia. The results showed that the anti-diabetic effect of the Tinospora cordifolia extract was to control blood sugar by alleviating the antioxidant effect, promoting insulin secretion and inhibiting gluconeogenesis and glycogen decomposition. It is suggested that the anti-diabetic effect of Tinospora cordifolia is related to its antioxidant effect.
2.Anti-diabetic chronic complications of 3-heart-leaf blue cattle gallbladder
2.1 Antidiabetic retinopathy
Diabetes mellitus has a history for more than 10 years. Most patients have retinopathy of varying degrees, which is one of the main causes of blindness. The anti-cataract activity, free radical scavenging activity and glucuronide reductase inhibitory activity of various plants including Cortex Isatidis and Morinda officinalis were studied.
2.2 Anti-diabetic nephropathy
The effects of anti-diabetic herbs, including Cortex Isatidis gall, on renal injury in streptomycin-induced diabetic rats were studied. The results showed that after oral administration of TC extract, the blood sugar concentration of diabetic rats decreased, polyuria could be prevented and urinary albumin content decreased.
In summary, the anti-diabetic effects of Tinospora cordifolia are mainly manifested in lowering blood sugar, correcting dyslipidemia, anti-oxidative stress, and reversibly inhibiting aldose reductase to improve metabolic disorders.
With the improvement of living standards, the number of people suffering from diabetes is increasing, so it is necessary to develop new safe and effective hypoglycemic drugs. As a anti-diabetic drug in India, Tinospora cordifolia is widely used in Ayurveda medical system. It has pharmacological activities such as lowering blood sugar, lowering blood lipid, anti-oxidative stress, and can prevent and treat diabetic retinopathy and diabetic nephropathy. It is a good natural anti-diabetic drug.
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