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Nicotinamide ribonucleoside is a kind of micronutrient in certain foods, such as milk and higher concentrations in supplemental supplement. Studies have shown that nutrients contain the unique properties of vitamin B-3. It can improve insulin sensitivity and the effect of exercise, protect the brain and resist the harmful effects of high-fat diet. Let's look at the nicotinamide and its effect.
The researchers recruited 24 healthy men and women from the Boulder area. They are between 55 and 79 years old and they are divided into two groups. One group took 500 mg of nicotinamide for 6 weeks and then treated with placebo for 6 weeks. The other group had the opposite pattern: they took a placebo for 6 weeks and then took a 500 mg nicotinamide for 6 weeks. The researchers analyzed the blood samples at the end of each treatment period and these people did other "physiological measurements". The results showed no serious complications.
The results showed that taking 1,000 mg of nicotinamide nucleoside per day can improve the levels of 60% nicotinamide adenine dinucleotide.
NAD has a beneficial effect on healthy aging and longevity. This compound is involved in many metabolic processes in the body, but it can decline with your body age.
One theory has been supported by research that when our food is too much, our body is evolved into a program that preserves NAD, and when we limit calorie intake, NAD is activated. Recently, the studies have also begun to investigate the elderly whether elder can more healthier taking nicotinamide. The results also found that in 13 patients with elevated blood pressure or grade 1 hypertension, adding nicotinamide can decrease contraction systolic blood pressure by 25%.
The researchers present evidence that their research is a step forward in supplementing the potential benefits of supplementing nicotinamide nucleosides to the elderly. There is still a lot of work that they hope to study more specifically the specific effects of nicotinamide on arterial health and blood pressure in clinical trials of size. Meanwhile, another trial is about to investigate the effects of such supplementation on mild cognitive impairment in the elderly, this situation often precedes Alzheimer's disease.
The role of nicotinamide ribonucleoside as a neuroprotective agent in humans
ChromaDex this company in California has licensed patents at Cornell University, Dartmouth College and Washington University in St. Louis.
Dr. Charles J. Brenner, Chairman of the University of Iowa's Roy J. Carver and Chairman of Biochemistry, and Dr. Charles Brenner, Chief Scientific Advisor of ChromaDex, discovered the nicotinamide nucleoside. Dr. Brenner commented: "Based on the new preclinical data and human safety data, we are pleased to have more animal studies to test the effects of nicotinamide nucleosides to improve the condition of human Alzheimer's disease."
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