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Do you know Bearberry extract?

Aug 19, 2019

Bearberry extract is from Bearberry. Bearberry is an ornamental evergreen plant that can be used as an ornamental plant. It can also be used as a soil and water conservation plant to prevent soil erosion. Because the leaves of bearberry are rich in tannic acid, they have been used to make leather. Bearberry leaves are low-lying, cold-tolerant, evergreen shrubs that grow on high latitudes in the northern hemisphere.


Bearberry can be used as a medicinal plant. Its leaves contain arbutin. Arbutin has an antibacterial effect, which is a mild diuretic that can be used to treat diseases of the urinary system, including cystitis and urinary calculi. Arbutin can also reduce the formation of melanin in the skin, has a whitening effect, and is used in cosmetics. The bearberry leaf extract is an active ingredient extracted from the dried leaves of the azalea plant bearberry, and the main components are arbutin and ursolic acid. Arbutin has antibacterial, antitussive, diuretic and other pharmacological activities, and is also an inhibitor of tyrosinase in human melanocytes. Arbutin can effectively inhibit the activity of tyrosinase in the skin. Blocks the formation of melanin, and directly combines with tyrosinase to accelerate the decomposition and excretion of melanin, thereby reducing skin pigmentation and eliminating pigmentation and freckles.

Bearberry extract

Pharmacological action

1.Antioxidant effect

 Ursolic acid is a strong antioxidant. Antioxidant has positive effects on anti-aging and skin freckle, sputum pigment and beauty. It can be applied to beauty and skin care products. Ursolic acid can significantly capture O2-, showing strong inhibition of lipid peroxidation in both liver microsomes and P45O monoamine oxidase system.

2. Anti-tumor effect

 Ursolic acid has an outstanding anti-tumor effect, and has a broad anti-tumor spectrum, and has a preventive and inhibitory effect on various stages of tumor growth and growth. It has a resistance to a variety of carcinogenic and carcinogenic substances, thereby inhibiting the formation of cancerous cells; it has obvious cytotoxic effects on a variety of malignant tumor cells, and has inhibitory effects on various tumor cells in vitro and in vivo, and can reduce release, Bad damage to the hematopoietic system after chemotherapy. Its anti-cancer and anti-cancer effects have attracted attention. It is foreseeable that ursolic acid may become one of the promising new anti-tumor drugs.

3. The effect on hepatitis

 Ursolic acid has obvious protective effect on acute experimental liver injury. The clinical manifestations are decreased serum alanine aminotransferase content, hepatocyte degeneration and necrosis, and can quickly restore liver function. It has quick effect, short course of treatment and stable effect. specialty. It has been clinically proven that ursolic acid can effectively treat viral hepatitis and is the main active ingredient of antiviral hepatitis drugs. Ursolic acid is used alone or in combination with other drugs in the preparation of a medicament for treating viral hepatitis, and has a remarkable effect of treating viral hepatitis as long as it is prepared into a medicine or a health care medicine.

4. Antibacterial and antiviral effects

 Ursolic acid can cause a decrease in cell viability, inhibit G+ and G-bacteria, and inhibit fungal growth. It has obvious effects on killing and inhibiting Streptococcus mutans and periodontal pathogens. Ursolic acid inhibits HIV-1 protease activity, enhances immune function, and exerts anti-HIV effects.

5. Whitening to remove pigmentation

 Arbutin has whitening activity, and its whitening mechanism is that arbutin can competitively and reversibly inhibit tyrosinase, thereby blocking the synthesis of dopa and dopaquinone, thereby inhibiting the production of melanin, thereby achieving whitening effect. However, arbutin does not affect the expression and synthesis of tyrosinase. In addition, ursolic acid also has anti-malarial effect, which can significantly reduce the proliferation of malaria parasites; lower blood pressure, anti-hyperlipemia, diuretic and hypoglycemic activities; it has certain toxicity to sperm and can be used as a contraceptive.

6. Other effects

 Studies have shown that the methanol extract of bearberry leaves (concentration 50%) has an inhibitory effect on tyrosinase. Arbutin has antibacterial, diuretic, astringent, anti-inflammatory and other effects. Hydroquinone and metabolites are produced in the urinary tract. In addition, ursolic acid has diuretic effect, tannic acid has a strong astringent effect, anti-cancer and anti-cancer effects, and allantoin can effectively resist skin ulcers.

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