SR9009

SR9009 is one of a pair of compounds developed at TSRI by Prius. The drug binds to Rev-erbα, a natural protein in the body that influences lipid and glucose metabolism in the liver, inflammatory responses, and fat-storing cells. By binding to Rev-erbα, SR9009 can kickstart metabolism with another pleasant side-effect: increased muscle strength.

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Now, after modulating Rev-erbα's activity with drugs, studies have shown its direct effect on skeletal muscles. With such strong results, Salus are pursuing funding that would focus primarily on the development of SR9009 and other similar compounds for safe use in humans. A new compound called SR9009 increases metabolism, fat burning, and muscle growth in the lab. Scientists at The Scripps Research Institute (TSRI) have successfully tested a drug, called SR9009, in mice that kickstarts metabolism and results in increased muscle development. Essentially, it's an exercise regime in a pill.

SR9009 alters the metabolic profile of skeletal muscle in a manner similar to the changes observed [in] animals [that] are endurance trained. Basically, the drug sends a signal to the muscle to tell it to modify its metabolism. Half of the mice studied showed improved running endurance in terms of both time and distance. What was clearly interesting was that a small, drug-like molecule could increase metabolic rate in skeletal muscle and increase exercise endurance.


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