Citrus Aurantium Extract Synephrine

Citrus Aurantium Extract Synephrine

1.Plant Source: Citrus sinsensis
2.Appearance: Brown Yellow powder
3.Main specification:6% 10% 30% HPLC
4.Used Herbal Part: Immature citrus fruit

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Citrus Aurantium Extract Synephrine actually has a very long history of use. The bitter orange plant is a native species to tropical Asia and eastern Africa.

Quick Details:

Plant Source

Citrus sinsensis



Brown Yellow powder

Extraction type

Main specification

6% 10% 30% HPLC

Cas No


Used Herbal Part

Immature citrus fruit


Pharmaceutical grade

Solvent Part

Testing method




Free Sample

10 g


Easily soluble in water;

Molecular Structure


Synephrine actually has a very long history of use. The bitter orange plant is a native species to tropical Asia and eastern Africa. It has a long history of being used as a medicinal plant in throughout Asia as well as in the Amazon rainforest.

It is a protoalkaloid compound and can be found in high level in bitter orange(citrus aurantium),standard citrus extract(71.5mg/kg or dry weigh;92.2% total protoalkaloids.)Its molecule is similar to ephedrine in mechanism as well as function, including increasing metabolic rate, inhibiting appetite and so on.Also , it may exert some minor health effects on digestion and circulation.It is widely used in varieties of field , such as dietary supplement ,pharmacy and food, beverage.

There is rising attention that the FDA issue regulation banning the sale of dietary supplement containing the ephedrine ,caused its potential safety risk to customers. It is the ingredient in dietary supplements being marketed as”ephedra-free” products for weight loss.

Citrus aurantium extract synephrine and related alkaloids appear to be present in slightly higher quantities in the unripe fruit than in the ripe fruit.

It levels in citrus fruits and peels ranged from as little 0.1% to a very high 2.0%, while most reports place the level at about 0.25%.


Safety Regualtiony:

Bitter orange flowers, peel, and peel oil are generally recognized as safe (GRAS) as foods according to the Food and Drug Administration ——(FDA)


1. Another factor that might mitigate in bitter orange's favor is its probable lower level of activitye than ephedra alkaloids, probably due, at least in part, to its absorption differences when ingested (i.e., compared to the i.v. route) and the possibility that it does not cross the blood-brain barrier.

2. The authors report that bitter orange-containing product does not cause any significant change in heart rate, systolic or diastolic blood pressure 60 minutes after ingestiongenerally referred to as a “fight or flight”

3. It reportedly enters into and is less active on the CNS than ephedrine (Jones, 1999). Therefore, it is believed to have fewer adverse effects on the beta 1 and 2 receptors than ephedrine (CNS,mean the centrol neverous system)


I. Weight-loss formulas usually contain 100-200 mg bitter orange extract, which provides 10-40 mg  per dose.” (NTP, 2004)

II. Extracts used in many dietary supplements and herbal weight-loss formulas as an alternative to ephedra have concentrations of the sympathomimetic alkaloid that are often much higher than the citrus aurantium extract synephrine concentrations reported for traditional extracts of the dried fruit or peel.



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