- Sep 12, 2017 -
What is Artemisinin？
Artemisinin is extracted from the leaves of Artemisia annua L., which is a kind of (3R, Hexahydro-6,2-triazolo [4,3-j] -1,2-benzene And dioxetine-10 (3H) -one. Molecular formula for the C15H22O5. It is a colorless needle-like crystal powder.
It is discovered from the Chinese Herbal Garden by Chinese Chinese scientist Tu Yo Yo.
Artemisinin is the most effective anti-malarial drug, especially for cerebellar malaria and chloroquine-resistant malaria, following the efficacy and efficacy of spiramine, chloroquine and lequine, which has been called the World Health Organization as " The only effective malaria treatment in the world. " The mechanism of malaria is mainly in the process of treatment of malaria through the activation of artemisinin free radicals, free radicals and malaria protein binding, acting on the malaria parasite membrane structure, so that the bubble film, nuclear membrane and plasma membrane were Destruction, mitochondrial swelling, inner and outer membrane shedding, thus the parasite cell structure and its function damage.
According to WHO statistics, about 240 million people in sub-Saharan Africa have benefited from artemisinin combination therapy since 2000, and about 1.5 million people have been killed by malaria because of the therapy. Therefore, many African people respect it as "Oriental God medicine".
In addition, the treatment of other diseases also show attractive prospects. Such as anti-schistosomiasis, regulate or inhibit the immune function of body fluids, improve lymphocyte conversion rate, gallbladder, expectorant, antitussive, asthma and so on.
Artemisinin can cure diabetes?
Artemisinin helps the Chinese pharmacy Tu Yo Yo won the Nobel Prize, in addition to known in the anti-malarial aspects of the significant role, but also recently a study that the drug may also be able to treat diabetes.
A breakthrough study published online in the May issue of the US magazine shows that artemisinin can produce α-cells that produce glucagon "transform" to produce insulin-beta cells, which means The drug will likely play an important role in the treatment of diabetes.
A study published in Cell magazine shows that scientists from institutions such as the CeMM Molecular Medicine Research Center of the Austrian Academy of Sciences have used a specially designed, fully automated analysis to examine the effects of a large number of approved drugs on artificially cultured alpha cells , And finally found the result.
According to the Science and Technology Daily, the study's author, Stefan Kubicek, said that the absolute and relative lack of insulin and the excessive activation of glucagon signaling pathways are two major causes of diabetes. Replacement of damaged cells with new cells that secrete insulin is expected to be a simple strategy for the cure of type 1 diabetes. Over the years, in order to achieve this, researchers around the world have used stem cells or mature cells to try a variety of methods.
But the long-term effects of artemisinin require further testing. Stefan Kubicek argues that the regeneration of human alpha cells is unknown. In addition, new beta cells must not be attacked by the immune system. But researchers believe that the discovery of artemisinin and their role models can lay the foundation for the development of new regimens for type 1 diabetes.
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