The fuction of Allium unifolium Kellogg extract

- Feb 26, 2018 -

Recently, a new study shows that an onion helps to fight some TB antibiotic resistance. Researchers believe that antimicrobial ingredients extracted from Persian onion can increase the effectiveness of existing antibacterial drugs.



The team tested four different molecules of Persian onion. The researchers found that there was a significant reduction in bacteria in MDR-TB, with a significant reduction, of which the most promising candidates were those that inhibited the growth of isolated TB cells more than 99.9 %.


This compound, extracted from Persian onion, is disulfide, one of these compound analogues having antimicrobial activity which inhibits the growth of M. tuberculosis at a concentration of 17 μM (4 mg L-1) Other analogues (ranged from 32 to 138 μM [8 to 32 mg L-1) inhibited Escherichia coli and multidrug-resistant Staphylococcus aureus. These compounds also have a certain inhibitory effect on Klebsiella and Proteus.

 

The team believes these compounds can be used with existing antibacterials to fight tuberculosis strains that are resistant to TB.


The researchers said they hope the molecules tested in the lab will combine with existing antibiotics to form new anti-TB drugs.


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