Parthenolide is a natural product of sesquiterpene lactone, which is isolated from medicinal plants such as chrysanthemum argyi and sightseeing wood. These plants are widely used in fever, insect repellent and anti-inflammatory.
Parthenolide can inhibit the growth of prostate cancer, breast cancer, gastric cancer, leukemia cancer, renal cancer, lung cancer, colorectal adenocarcinoma, neuroblastoma and other cancer cells in recent studies. In animal models, parthenolide can also treat the skin cancer caused by ultraviolet rays.
Parthenolide plays an anti-inflammatory role by inhibiting the phosphorylation of ikB protein and the activation of NF-KB by intracellular mechanisms.
- Suppression of Innate Immunity
Parthenolide can inhibit the inflammatory protein assembly of a group of oligomeric molecules in the innate immune system.
Autosomal recessive polycystic nephropathy is caused by the PKHD1 gene mutation encoding transmembrane receptor-like protein fi-brocystin/polyductin. Renal cells lacking FC1 will result in decreased ERKI/2 kinase activity, leading to up-regulation of apoptotic protein p53 and activation of nf-kb, thereby leading to apoptosis.
Parthenolide blocks the activation of ikk-dependent nf-kb, reduces the apoptosis of renal cells lacking FC1 and the level of apoptotic protein p53, and opens up a new research field for the treatment of autosomal recessive polycystic kidney disease.
- Oxidative Stress
Parthenolide can inhibit the secretion of TNFot, il-1b, il-6 and the activation of cox-2, so as to protect white blood cells from stress injury induced by hemodialysis without obvious toxic and side effects.
Parthenolide and its analogue lc-1 are capable of acting alone or in combination against hematopoietic cells, including acute myeloid leukemia, pre-b cell type acute and chronic lymphocyte leukocytes.
Study shows that Parthenolide by inhibiting megakaryocyte NF - KB enhanced platelet product can be independent of the induced oxidative stress response, feverfew lactone in enhancing function of platelet product at the same time reduce unnecessary blood activation, other studies have also suggest Parthenolide can directly the dependence to enhance platelet product.
Parthenolide has antiviral activity.
As a kind of precursor compounds, feverfew lactone in half of effective concentration can in genomic RNA replicators determination system against hepatitis c virus replication, add a successful antiviral treatment need cocktail therapy, in hepatitis c virus (HCV) replication subsystem, a combined interferon after feverfew lactone added effect.
STORAGE: Cool & Dry Place, away from strong light and heat
PACKAGE: 10g/one bag
Customization according to customers' request.
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